Centre for Molecular and Nanomedical Sciences

About the Centre (CMNS):

The Centre was emerged from the Nanomedicine and Drug Discovery Lab in 2012 at the University campus to accomplish the goal of enhancing advanced research in the area of nanomedicine and drug discovery. Further the lab was expanded as Molecular and Nanomedicine Research Unit in 2014. The leading area of research includes Neuroscience, Neurodegenerative disorders, Infectious Disease Biology, Cardiovascular Biology, Cancer Biology, Organic Chemistry, Regeneration and Stem Cell Biology. In recognition of the research progress and academic activities the Molecular and Nanomedicine Research Unit has been elevated as Centre for Molecular and Nanomedical Sciences from 2019 for further research developments. In addition to research, the Centre also conducts training programs, workshops and conferences. The Centre is undertaking research and development projects from various agencies and research organizations in India and abroad.

Vision:

To establish technologies for developing high throughput screening of small drug molecules, 3D organoids, ex-vivo organ development, translational research in the field of Molecular and Nanomedical Sciences through Research, Awareness and Consultancy.

Mission:

1. To innovate and implement advanced high-throughput screening platforms for small molecule discovery, accelerating drug development and precision medicine.

2. To develop and apply cutting-edge 3D organoid and ex-vivo organ systems that enable breakthroughs in disease modelling and regenerative medicine.

3. To bridge the gap between laboratory research and clinical application by promoting translational research, fostering public awareness, and providing expert consultancy in Molecular and Nanomedical Sciences.

Research activities:

Research activities of Centre for Molecular and Nanomedical Sciences:

Current research 

  • Cancer Biology Lab: Studying the molecular mechanism of angiogenesis development in breast cancer using Rat and mouse breast cancer models and also discovering novel drugs from marine sponge associated symbionts. Also, Exploring the molecular mechanisms of cancer therapeutics in different cancer models. 

  • Neuroscience Lab: Studying the role of phytochemicals in neural stem cell regeneration and their potential in targeting neurodegenerative disorders, with a focus on 3D spheroids and organoid models.

  • Synthetic Biology Lab: Targeting microbial therapeutic enzymes and extremozymes (streptokinase (SK), tissue plasminogen activator (tPA), urokinase (UK) and nattokinase, Lipases and proteases, using latest synthetic biology techniques.

  • Regeneration and Stem cell Biology Lab: Developing serum free alternative for Fetal Bovine serum for animal cell culture using earthworm coelomic fluid. Developing cryomedium for Stem cell storage and organoid storage. Providing scientific molecular evidences for traditional medicines practised in southern India. Profiling the miRNAs, stem cell niche and exploring molecular potential behind it.

  • Molecular Biology and Stem Cell Research Lab: Focused on developing an ex-vivo organ model for prostate, testis, ovary and skin from a diversity of invertebrates and lower vertebrate species for disease modelling, toxicological pathology, drug screening, cancer modelling and reproductive toxicological studies. Exploring the intricate molecular pathways of programmed cell death that influence regeneration and cancer studies.

  • Stress and Cardiovascular Biology Lab: Understanding the Molecular regulation of the stress related proteins in the different cardiac disease.

 

Future research directions:

  • Cancer Biology Lab: Finding new therapies to reduce the side effects caused by conventional cancer therapies and exploring their molecular mechanisms using different cancer model systems.

  • Regeneration and Stem cell Biology Lab: To develop organoid model for understanding the molecular mechanism of regeneration for testing preclinical drug candidates.

  • Molecular Biology and Stem Cell Research Lab: Ex-vivo organ culture, regeneration augmentation, stem cells regulation, apoptotic induced compensatory proliferation, photobiology and molecular docking studies.

  • Neuroscience Lab: Exploring neural stem cell-based therapy and developing disease models, particularly cerebral organoids for neurodegenerative disorders.

  • Synthetic Biology Lab: Development the plant and Microbial protein based therapeutic Peptides and Peptidomimetics for Cardiovascular Diseases.

  • Stress and Cardiovascular Biology Lab: Exploring the underlying mechanisms regulating cardiovascular disease and understanding the molecular changes induced by cardiometabolic diseases, with a focus on targeting various molecular pathways.

Facilities: 

Confocal Microscopy Facility with NSPARC Technology

Flowcytometry

CytoFLEX – Beckman Coulter

Ultracentrifuge

Beckman coulter – Ultima XPN-100 Ultra centrifuge

Hi-speed Centrifuge

 

Allegra X-30, Benchtop Centrifuge

 

 

CelVIVO-3D organoid Incubator

 


 

BTX Electroporator

 

 

Celloger Mini Plus Live Cell Imager

 

 

Cryomicrotome

 

Automatic tissue processor

 

Faculty

Sl. NoName of the facultiesDesignationQualification

Field of expertise

Contact

1.Dr. A. DayanandanProfessor - ResearchMSc., PhD.,Enzyme technology

[email protected]

Ph: 9952045791

2. Dr. A. Madan KumarAssistant Professor - ResearchMSc., PhD.,Cancer Biology

[email protected]

ph: 9942110146

3.Dr. S. Johnson Retnaraj SamuelAssociate Professor - ResearchMSc., PhD.,Regeneration and stem cell biology

[email protected]

Ph: 8012261482

4.Dr. S. Jackson DurairajAssociate Professor - ResearchMSc., PhD.,Regeneration and stem cell biology

[email protected]

Ph: 9655049326

5.Dr. M. RajasekarAssistant Professor - ResearchMSc., PhD.,Synthetic organic and medicinal chemistry

[email protected]

Ph: 9710230530

6. Dr. Y. Beryl VedhaAssistant Professor - ResearchMSc., M.Phil., PhD.,Neuroscience

[email protected]

Ph: 8144309580

7. Dr. Joyita HazraAssistant Professor - ResearchM.Sc., Ph.D., Stress and cardiovascular disease

[email protected] 

Ph: 8220297383

8Dr. Nandha GopalAssistant Professor - ResearchM.Sc., Ph.D.,Neuroscience and embryology

[email protected]

Ph: 9789370522

Scientific Assistant

  • Mr. Saravanakumar V
  • Mr. Kesavamoorthy V

Research Fellow:

Mr. V. Saravanakumar

Scientific Assistant

M.Sc., 

Mr. S. Ravichandran

Junior Research Fellow

M.Sc.,  

Ms. Melinda Grace

Junior Research Fellow

M.Sc.,  

Mrs. Janice. R

Junior Research Fellow

M.Sc.,  

Mr. Jenif Leo Anandharaj

Project Associate

M.Sc.,

Ms. Reethu V

IRF – Institutional Research Fellow 

M.Sc.,

Mr. Abdulla Mohammed

Research Scholar

M.Sc.,

Mr. Kesavamoorthy V

Scientific Assistant

M.Sc.,

Mrs. Srilakshmi

IRF – Institutional Research Fellow

M.Sc.,

Ms. Reiya Bosco D

Research Scholar

M.Sc.,

Ms. Shana Balachandran

IRF – Institutional Research Fellow

M.Sc.,

Mohana Priya S

Research Scholar

M.Tech.,

AJith C

Research Scholar

M.Sc.,

National – Post Doctoral Fellows:

  • Dr.Sundar Raj (2018-2020) - DST

  • Dr.D.Jayakar Santhosh (2017-2019) - DST

  • Dr.N.Jhansi Rani (2017-2019) - DST

  • Dr.M.V.Sujitha (2017-2019) - DST

  • Dr.M.Rajasekar (2016-2018) - DST

  • Dr.N.Nagasundaram (2016-2018) – DST

Consultancy Services: 

Centre for Molecular and Nanomedical Sciences is providing following consultancy services for academics and industries;

  1. Confocal Microscopy

  2. Organoid incubator

  3. Real time PCR

  4. Multimode Plate reader

  5. ELISA washer

  6. Cryomicrotome

  7. Automatic tissue processor

  8. Electroporator

  9. Microinjector

  10. Fluorescence Microscopy facility

  11. Flow Cytometry

  12. Ultracentrifuge

  13. Fermentor 

  14. Nanopore Sequencer

  15. ChemiDoc XRS+ System and Western Blotting

  16. Cell Culture Facilities and Assays

  17. Qubit Fluorometer

  18. GC-FID

  19. HPLC-PDA

  20. Stereo Microscope with Fluorescence

  21. Toxicity assay in Zebrafish

  22. Proximate Analysis

  23. Nanodrop

  24. Development of Transgenic Zebrafish development

  25. Anticancer studies – In vitro cell line study

 

Projects

SL

No

Title of Project

Funding Agency

Principle investigators

Start and End Date

Approved cost

1

Screening and molecular characterization of Flk-1 inhibitor(s) from marine sponge symbionts and real time molecular imaging studies 

Department of Science and Technology -SERB 

Dr. A. Madan Kumar

March-2015 to March 2018

25,00,000

2

Studies on the anticancer mechanisms of PI3K inhibitor(s) from marine sponge symbionts 

Department of Biotechnology - Govt. of India

Dr. A. Madan Kumar

April-2016 to Septembar-2019

28,67,000

3

Nanoparticle based Biosensor for deduction of leptospira from environmental and clinicalsamples 

Department of Science and Technology -SERB 

Dr. Jayakar Santhosh & Dr.A. Madan Kumar

June -2016 to May-2018

16,20,000

4

Anticancer activity of crude extracts from T.violacea on human oral cancer cells

DST- RTF-DCS 

Ms. Samkeliso & Dr.A. Madan Kumar

June-2017 to June 2018

2,70,000

5.

Understanding the role of Triphala in tissue regeneration and stem cell proliferation

DBT- Foldscope Project

Dr. S. Jackson Durairaj 

26-06-2018

to

25-12-2019

 

Rs 8,00,000

6.

Silencing of TCTP gene expression to study the regeneration in earthworm Perionyx excavatus

DST-SERB

Dr. S. Jackson Durairaj 

01-04-2019 to

29-06-2022

Rs 37,45,043

7.

In-vitro functional organ model development for prostate cancer and its molecular characterization.

Department of Health Research (DHR) 

Dr. S. Jackson Durairaj 

05-08-2020 to 04-08-2023

Rs 29,85,000/-

8.

Analysis of atrazine induced pathological variation associated with Alzheimers disease using a zebrafish genetic model.

SERB-OVDF 

Dr. S. Jackson Durairaj 

11-01-2022 to

09-07-2023 

Rs 31,20,000/-

9.

Earthworm a unique model to monitor the electromagnetic hazards associated with the exposure of high voltage overhead electric lines

TNSCST (Minor project)

Dr. S. Jackson Durairaj

11-03-2022

to

10-07-2022

 

Rs 7,500/-

10.

Preserving the tribal practice and exploring the molecular level evidence behind the use of spider web for wound healing and abscess. 

DST-SHRI 

Dr. S. Jackson Durairaj 

28-03-2022 to  

02-12-2024

Rs 20,80,000/-

11.

Identification and Characterization of molecular link between lamin A and Telomere in the context of aging.

SERB

Dr. S. Johnson Retnaraj Samuel

04/04/2016 to 04/07/2019

Rs 27,50,000/-

12.

 Understanding the angiogenesis during regeneration of earthworms using foldscope.

DBT

Dr. S. Johnson Retnaraj Samuel

24/05/2018 to 19/09/2019

Rs 8,00,000/-

13.

Molecular mechanism and multicolour imaging of ar-turmerone on neuro-regeneration.

ICMR-RA

Mentor: Dr. S. Johnson Retnaraj Samuel

05/03/2019 to 04/03/2022

Rs 22,59,600/-

14.

Characterization of targeted small molecules for drug development, isolated from regenerating earthworms having potential wound healing and anti-bacterial properties.

ICMR

Dr. S. Johnson Retnaraj Samuel

09-04-2020

to

08-04-2021

Rs 

8,34,118/-

15.

Production, characterization and scaling-up of earthworm coelomic fluid based serum-free cell culture medium for animal cell culture

BIRAC

Dr. S. Johnson Retnaraj Samuel

21-11-2020 to

20-11-2022

Rs 27,00,000/-

16.

Exploring an extinct heritage food “Marunthu Kulambu” used for rejuvenating the health of postpartum women and evaluating its scientific importance.

DST

Dr. S. Johnson Retnaraj Samuel

23-03-2022 to 

22-03-2024

Rs 15,69,282/-

17.

Molecular mechanistic role of ar- turmerone, a promising drug candidate for the treatment of Parkinson’s disease.

SERB-POWER

Dr. Y. Beryl Vedha

2022- 2025

Rs   

27,13,425/-

18.

Foldscope: Multicolor imaging of zebrafish brain using fluorescent

sorbitol conjugates.

DBT

Dr. M. Rajasekar

24/05/2018 to

19/09/2019

Rs 8,00,000/-

19.

Development of venom based antiepileptic peptide targeting Na

channels and deciphering the mode of action in Zebrafish model.

ICMR

Dr. RP. Rajesh

2020-2022

Rs 20,00,000/-

20.

Sustainable livelihood development through the production of high quantity and quality meat from the backyard poultry farming using enzymes.

DST - SEED

Dr. A. Dayanandan;

Dr. S. Johnson Retnaraj Samuel; Dr. S. Jackson Durairaj; Dr. Shyju.

2023-2025

Rs 

67,72,460/-

21.

Standardization and Development of Lab grown meat (Goat) and corresponding cost effective medium

Sathyabama SEED Grant

Dr. S. Johnson Retnaraj Samuel; Dr. S. Jackson Durairaj; Dr. Y. Beryl Vedha

2023-2024

Rs 

5,57,749/-

22.

Training on Biomedical techniques in Modern Biology.

DHR

Dr. S. Johnson Retnaraj Samuel; Dr. S. Jackson Durairaj; Dr. Y. Beryl Vedha; Dr. Joyita Hazra

2024-2029

Rs 38,85,000/-

Patents

  • Dr. S. Johnson Retnaraj Samuel and Dr. S. Jackson Durairaj are the lead inventor of the Indian patent, entitled on, ‘Alternative supplement for serum in animal cell culture medium”, Granted; Patent No. 487479 dated on 22/12/2023.

  • Dr. M. Rajasekar is the lead Inventor in Indian patent entitled on “Synthesis of Naringenin and analogues with biocompatibility studies in zebrafish for therapeutic potential” E-101/5704/2020-CHE, 10/03/2020.

  • Madan Kumar and S.N. Nagabhishek “Monocolin x from marine sponge as an apoptosis inducing molecule” - R20194010495.

  • Madan Kumar. Active PI3K inhibitor molecule from marine sponge associated bacillus pumilus AMKI - R20194010499.

  • Dr. S. Johnson Retnaraj Samuel et al., Indian patent, entitled on, ‘Earthworm Coelomic fluid as a potential blocking agent in western blotting experiments.”, Application number 202041055479 – 21/12/2020.

  • Dr. S. Johnson Retnaraj Samuel, Ms. Melinda Grace, Mr. S. Ravichandran, Mr. V. Saravanakumar, Dr. Y. Beryl Vedha and Dr. S.Jackson Durairaj, ‘Formulated heat inactivated coelomic fluid-based serum free media for adherent primary cells and cell lines’, Application number 202341009593 – 14/02/2023.

  • Dr. S. Johnson Retnaraj Samuel, Ms. Melinda Grace, Mr. S. Ravichandran, Mr. V. Saravanakumar, Mr. Kesavamoothry, Dr. Y. Beryl Vedha and Dr. S.Jackson Durairaj, ‘Synthetic serum-free plant-based alternative to FBS for culturing adherent cells and cell lines’, Application number 202441080501– 23/10/2024.

  • Dr. Y. Beryl Vedha and Dr. S. Johnson Retnaraj Samuel, Mr. Jenif Leo Anandharaj, Ms. V. Srilakshmi, Ms. S. Bharishi, Ms. S. Divya and Ms. P. Harini. ‘Novel cost-effective method for the isolation and characterization of aromatic turmerone from Curcuma longa rhizomes’. Application number 202441086686 – 11/11/2024.

  • Dr. Y. Beryl Vedha and Dr. S. Johnson Retnaraj Samuel, Mr. Jenif Leo Anandharaj, Ms. V. Srilakshmi, ‘Neuroprotective efficacy of ar-turmerone and its modulatory role in microglial-mediated neuroinflammation’. Application number 202441086682 – 11/11/2024.

  • Dr. S. Jackson Durairaj, Mr. R. Kamarajan and Kunal Biswas. A deep root watering system for enriching nutrient value of root water. Application number 202241036037 dated granted on 17/12/2024

Publications

  1. Devi, H.J., Gnanasekaran, P., Kumar, A.M. et al. Unveiling the Antibacterial, Antifungal, and Cytotoxic Potential of Selenium Nanoparticles Synthesized with Syzygium cumini Leaf Extract. J Clust Sci 36, 60 (2025). https://doi.org/10.1007/s10876-025-02777-3.

  2. Bhalodiya SS, Parmar MP, Patel CD, Patel SG, Vala DP, Suresh N, Jayachandran B, Kumar Arumugam M, Narayan M, Patel HM. Acetic Acid-Driven One-Pot Synthesis of 4,7-dihydro-[1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxamides and Pharmacological Evaluations. ChemMedChem. 2025 Jan 14;20(2):e202400595. doi: 10.1002/cmdc.202400595.

  3. Prathiba Gnansekaran, Anitha roy, Nagabhishek Sirpu Natesh, Varshini Raman, Priyanka Ganapathy, A. Madan Kumar. Removal of microbial pathogens and anticancer activity of synthesized nano-thymoquinone from Nigella sativa seeds. Environmental Technology and Innovations, 24 (2021) 102068 (impact Factor – 7.758). 

  4. Ronald Merckx, Gopala Krishnan Durairaj, Saravanan, A. Madan Kumar, Themmila Khamrang, Hoogenboom Richard, Mani Ganeshpandian. N,N-Ru(II)-p-cymene- poly(N-vinylpyrrolidone) surface functionalized gold nanoparticles: from organorutheium complex to nanomaterial for antiproliferative activity. Dalton Transaction, (2021) 50, 8232-8242 (Impact Factor- 4.39). 

  5. Palanisamy Govindasamy, Nora Hamad Al-shaalan, Bhuvaneswari Kandasamy, Bharathi, Govindan, A. Madan Kumar, A. Elmarghany. An efficient and magnetically recoverable g-C3N4/ZnS/CoFe2O4 nanocomposite for sustainable photodegradation of organc dye under UV-visible light illumination. Environmental Research 201, (2021) 111429 (Impact Factor – 8.431). 

  6. M. Rajasekar, Review of photoresponsive and glycoside dendrimers in biomaterials and sensors applications. RSC Adv., 2022, 12, 35123-351505.

  7. M. Rajasekar, InCl3-Catalyzed One-Pot Three-Component Aza-Friedel-Crafts Reactions (AFCR) of 3-Substituted Indole Derivatives and its in-Silico Mcl-1 Inhibition Studies. J. Org. Inorg. Chem, 2022, 8, 1-5.

  8. M. Rajasekar, Gel Scaffolds and emerging applications in biomedicine. RSC Adv., 2022, 12, 15925-15949.

  9. M. Rajasekar, Spirobifluorene derivatives and their biomaterial applications: Current Trends, J. Mol. Struct., 2022, 12, 132406.

  10. M. Rajasekar, Identification and characterisation of novel wasp mastoparans and chemotactic peptides from the venom of social wasp Polistes stigma (Hymenoptera: Vespidae: Polistinae), J. Venom. Res, 2021, 11, 16-20.

  11. M. Rajasekar, Adverse effect of synthesized Naringenin derivatives investigates with Zebrafish (Danio rerio) embroys. Results. Chem., 2020, 2, 100039

  12. M. Rajasekar, Self-assembly of sugar-based glyco-lipids: Gelation studies of partially protected β-glucose derivatives. Mater. Sci. Eng. C., 2018, 93, 776-781

  13. M. Rajasekar, In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliates ICN25 in zebrafish embryos. Microb. Pathog, 2017, 112, 76-82

  14. Sirpu Natesh Nagabhishek, A Madan Kumar, Sambhavi B, Anandan Balakrishnan, Suvro Chatterjee. A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling. RSC Adv., 2019, 9, 26646-26667 (Impact Factor-3.049). 

  15. Theerthagiri J, Sunitha Salla, R A Senthil, P Nithyadharseni, A Madankumar, Prabhakarn Arunachalam, T Maiyalagan and Hyun-Seok Kim. A review on ZnO nanostructured materials: energy, environmental and biological application. Nanotechnology 30 (2019) 392001 (27pp) (Impact Factor-3.3). 

  16. Elamathia, A. Madankumar, Werner Kaminsky, R. Prabhakarana. Synthesis, spectroscopic studies and biological evaluations of copper(I)/(II) metallates containing nitrogen heterocycles. Inorganica Chimica Acta 496 (2019) 119039 (Impact Factor- 2.450). 

  17. Mariadhas V A, A. Madankumar, J. Theerthagiri, Sunitha Salla, S. Prabu, Hyun-Seok Kim, Naif Abdullah Al-Dhabi, Selvaraj Arokiyaraj, Veeramuthu Duraipandiyan. Synthesis and characterization of ZnO nanoflakes anchored carbon nanoplates for antioxidant and anticancer activity in MCF7 cell lines. Materials Science & Engineering C 102, 2019. 536–540 (Impact Factor- 4.959). 

  18. Gayathri karanam, A Madankumar, S N Nagabhishek. Anticancer Effect of Marine Sponge Associated Bacillus pumilus AMK1 Derived Dipeptide Cyclo (ProTyr) in Human Liver Cancer Cell Line Through Apoptosis and G2/M Phase Arrest. International Journal of Peptide Research and Therapeutics, pp 1–13, 2019 (Impact Factor- 1.219). 

  19. Elamathi, C. Madan Kumar A. Werner Kaminsky, R. Prabhakaran, Synthesis, spectroscopic studies and biological evaluations of copper(I)/(II) metallates containing nitrogen heterocycles. Inorganica Chimica Acta. Volume 496, 2019, 119039. ISSN 0020-1693. 

  20. Karanam, G., Madan Kumar A*. Sirpu Natesh, N. Combination of ZnO Nanoparticle with Marine sponge derived Dipeptide for enhances anticancer efficacy in Liver cancer cells and their toxicity evaluation in embryonic zebrafish. Current analytical chemistry. 2020. 

  21. SN Nagabhishek, Madan Kumar A *, Gayathri karanam. Apoptotic role of marine sponge symbiont Bacillus subtilis NMK17 through the activation of caspase-3 in human breast cancer cell line. Molecular Biology Reports, 2018. (PMID: 30414102)  

  22. Antony V. Samrot, B. Suvedhaa, Chamarthy Sai Sahithya, Madan Kumar A. Purification and Utilization of Gum from Terminalia Catappa L. for Synthesis of Curcumin Loaded Nanoparticle and Its In Vitro Bioactivity Studies. Journal of Cluster Science, 2018, Volume 29, Issue 6, pp 989–1002 

  23. Madan Kumar. A, Tamilarasi. S, Premkumar. T, Gopikrishnan M, Nagabhishek. N, Devaki T. Geraniol attenuates 4nqo induced tongue carcinogenesis through downregulating the activation of NF-κB in rats. Mol Cell Biochem. 2017. (PMID: 28397014)

  24. Seung Jun Lee, Jayaraman Theerthagiri, Palaniyandy Nithyadharseni, Prabhakarn Arunachalam, Dhandapani, A Madan Kumar, Jagannathan Madhavan, Vikas Mittal, Myong Yong Choi. Heteroatom-doped graphene-based materials for sustainable energy applications: A review. Renewable and Sustainable Energy Reviews 143 (2021) 11084. (Impact Factor-16.799). 

  25. Antony Samrot, Lavanya Agnes Angalene, A. Madan Kumar and SureshKumar. Purification, characterization and exploitation of Azadirachta indica gum for the production of drug loaded nanocarrier. Materials Research Express, 7 (2020) 055007. (Impact Factor-1.41). 

  26. Gayathri Karanam, A. Madan Kumar. Reactive oxygen species generation and mitochondrial dysfunction for the initiation of apoptotic cell death in human hepatocellular carcinoma HepG2 cells by a cyclic dipeptide Cyclo(-Pro-Tyr). April (2020). Molecular Biology Reports (Impact Factor-2.107). 

  27. Durairaj G.K, Chezhiyan S, A. Madan Kumar, Nattamai S.P, Suvankar G, Priyadip D, Mani Ganeshpandian. Encapsulation of Ru(n6-p-cymene) complex of the antibacterial drug trimethoprim into a polydiacetylene phospholipid assembly to enhance its in vitro anticancer and antibacterial activities. New J. Chem., (2020) 44, 20047-20059 (Impact Factor – 3.591). 

  28. Chennakrishnan, F. R. Fronczek, A. Madan kumar and R. Prabhakaran. Synthesis and spectral characterizations of water soluble Cu(II) complexes containingNheterocyclic chelates: cell-proliferation, antioxidant and nucleic acid/serum albumin interactions. New J. Chem., (2020), DOI: 10.1039/C9NJ04136B. (Impact Factor-3.591). 

  29. Gayathri Karanam, A. Madan Kumar. Combination of ZnO Nanoparticle with Marine Sponge Derived Dipeptide for Enhanced Anticancer Efficacy in Liver Cancer Cells and their Toxicity Evaluation on Embryonic Zebrafish. January 2020. Current Analytical Chemistry (Impact Factor-1.242). 

  30. Elamathi, R. J. Butcher, A. Mohankumar, P. Sundararaj, A. Madankumar, P. Kalaivanie and R. Prabhakaran. A quinoline-based probe for effective and selective sensing of aspartic acid in aqueous medium: in vitro and in vivo live cell imaging. Inorg. Chem. Front., 2019, 6, 3237 (Impact Factor-5.165). 

  31. Antony V.Samrot, Lavanya AgnesAngalene, Roshini, Stefi, A. MadanKumar, SureshKumar. Purification, characterization and utilization of polysaccharide of Araucaria heterophylla gum for the synthesis of curcumin loaded nanocarrier. International Journal of Biological Macromolecules. Volume 140, 2019, Pages 393-400 (Impact Factor-4.784). 

  32. Saleem S, Kannan RR. Zebrafish: A Promising Real-Time Model System for Nanotechnology-Mediated Neurospecific Drug Delivery. Nanoscale Research Letters. 2021 Dec;16(1):1-4. https://doi.org/10.1186/s11671-021-03592-1 IF: 4.46

  33. Sundarraj S, Sujitha MV, Alphonse CR, Kalaiarasan R, Kannan RR. Bisphenol-A alters hematopoiesis through EGFR/ERK signaling to induce myeloblastic condition in zebrafish model. Science of The Total Environment. 2021 Sep 15; 787:147530. https://doi.org/10.1016/j.scitotenv.2021.147530 IF: 10.7

  34. Mary TR, Kannan RR, Iniyan AM, Vincent SG. Statistical optimization of fermentation media for beta lactamase inhibitor kalafungin production from marine Streptomyces sp. SBRK1. Journal of Applied Biology and Biotechnology. 2021 Apr 20;9(3):8-7. http://dx.doi.org/10.7324/JABB.2021.9312 IF: 0.85

  35. Kesh S, Kannan RR. Neuroprotective Effect of Tephrosia purpurea Against Mitochondrial Dysfunction by Regulation of the Caspase3/9 and Pink1/Parkin Complexes. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2021 Apr 1;11(2):137. https://www.ijnpnd.com/text.asp?2021/11/2/137/314375 IF: 0.62

  36. Mary TR, Kannan RR, Iniyan AM, Ramachandran D, Vincent SG. Cell wall distraction and biofilm inhibition of marine Streptomyces derived angucycline in methicillin resistant Staphylococcus aureus. Microbial Pathogenesis. 2021 Jan 1; 150:104712. https://doi.org/10.1016/j.micpath.2020.104712 IF: 3.738

  37. Kesh S, Kannan RR, Sivaji K, Balakrishnan A. Hesperidin downregulates kinases lrrk2 and gsk3β in a 6-OHDA induced Parkinson’s disease model. Neuroscience Letters. 2021 Jan 1; 740:135426. https://doi.org/10.1016/j.neulet.2020.135426 IF: 2.81

  38. Kesh S, Kannan RR, Balakrishnan A. Naringenin alleviates 6-hydroxydopamine induced Parkinsonism in SHSY5Y cells and zebrafish model. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2021 Jan 1; 239:108893. https://doi.org/10.1016/j.cbpc.2020.108893 IF: 3.22

  39. Nathan J, Kannan RR. Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research. Heliyon. 2020 Dec 1;6(12): e05662. https://doi.org/10.1016/j.heliyon.2020.e05662 IF: 

  40. Pitchai A, Kannan RR, Mani R, Nagarajan N. Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer's disease. Heliyon. 2020 Sep 1;6(9): e04930. https://doi.org/10.1016/j.heliyon.2020.e04930 IF: 2.85

  41. Persia Jothy T, Kannan RR, Subramoniam T. Lipid and carotenoid metabolism in the developing embryos of the intertidal anomuran crab, Emerita asiatica (Milne Edwards). Invertebrate Reproduction & Development. 2019 Jul 3;63(3):135-45. https://doi.org/10.1080/07924259.2019.1608325 IF: 1.68

  42. Saleem S, Kannan RR. Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery. Cell death discovery. 2018 Oct 3;4(1):1-3. https://doi.org/10.1038/s41420-018-0109-7 IF: 4.53

  43. Pitchai A, Nagarajan N, Vincent SG, Kannan RR. Zebrafish bio-assay guided isolation of human acetylcholinesterase inhibitory trans-tephrostachin from Tephrosia purpurea (L.) Pers. Neuroscience Letters. 2018 Nov 20; 687:268-75. https://doi.org/10.1016/j.neulet.2018.09.058 IF: 2.81

  44. Nagarajan N, Chellam J, Kannan RR. Exploring the functional impact of mutational drift in LRRK2 gene and identification of specific inhibitors for the treatment of Parkinson disease. Journal of Cellular Biochemistry. 2018 Jun;119(6):4878-89. https://doi.org/10.1002/jcb.26703 IF: 4.429

  45. Nagasundaram N, Wilson Alphonse CR, Samuel Gnana PV, Kannan RR. Molecular dynamics validation of crizotinib resistance to ALK mutations (L1196M and G1269A) and identification of specific inhibitors. Journal of Cellular Biochemistry. 2017 Oct;118(10):3462-71. https://doi.org/10.1002/jcb.26004 IF: 4.429

  46. Carlton Ranjith W.A.; Rajesh Kannan, R.; Nagarajan, N. PITRM1 Interaction Studies with Amyloidogenic Nonapeptide Mutants of Familial Alzheimer’s Disease. J. Biomol. Struct. Dyn. 2022, 1–12, doi:10.1080/07391102.2022.2092554.(IF 5.23)

  47. Carlton Ranjith W. A.; Rajaretinam, R.K. Habituation and Behavioural Response of Confinement-Induced Anxiety Conditions in a Zebrafish Model. Appl. Biosci. 2022, Vol. 1, Pages 315-323 2022, 1, 315–323, doi:10.3390/APPLBIOSCI1030020.

  48. Sundarraj, S.; Sujitha, M. V; Carlton Ranjith W. A, Kalaiarasan, R.; Kannan, R.R. Bisphenol-A Alters Hematopoiesis through {EGFR}/{ERK} Signaling to Induce Myeloblastic Condition in Zebrafish Model. Sci. Total Environ. 2021, 787, 147530, doi:10.1016/j.scitotenv.2021.147530. (IF 10.75).

  49. Sundarraj, S.; Muneeswaran, S.; Carlton Ranjith W. A.; Sujitha, M. V.; Soundharapandiyan, N.; Rajendran, V.; Kannan, R.R. The UV-B Protective Effect of a SiO2 Doped TiO2 Thin Film Regulates Pitx3 and Sparc Expression during Embryonic Development of Zebrafish. Environ. Sci. Nano 2022, 9, 3809–3820, doi:10.1039/d2en00236a. (IF 9.47).

  50. Haridevamuthu, B.; Manjunathan, T.; Carlton Ranjith W. A.; Kumar, R.S.; Thanigaivel, S.; Kishore, S.C.; Sundaram, V.; Gopinath, P.; Arockiaraj, J.; Bellucci, S. Functionalized Sulfur-Containing Heterocyclic Analogs Induce Sub-G1 Arrest and Apoptotic Cell Death of Laryngeal Carcinoma In Vitro. Molecules 2023, 28, 1856, doi:10.3390/molecules28041856. (IF 4.92).

  51. Kundu, B.K.; Pragti; Carlton Ranjith W. A.; Shankar, U.; Kannan, R.R.; Mobin, S.M.; Bandyopadhyay, A.; Mukhopadhyay, S. Cancer-Targeted Chitosan–Biotin-Conjugated Mesoporous Silica Nanoparticles as Carriers of Zinc Complexes to Achieve Enhanced Chemotherapy In Vitro and In Vivo. ACS Appl. Bio Mater. 2022, 5, 190–204, doi:10.1021/acsabm.1c01041. (IF 3.95)

  52. Haridevamuthu, B.; Manjunathan, T.; Guru, A Carlton Ranjith W. A.; Boopathi, S.; Murugan, R.; Gatasheh, M.K.; Hatamleh, A.A.; Juliet, A.; Gopinath, P.; et al. Amelioration of Acrylamide Induced Neurotoxicity by Benzo[b]Thiophene Analogs via Glutathione Redox Dynamics in Zebrafish Larvae. Brain Res. 2022, 1788, 147941, doi:10.1016/j.brainres.2022.147941. (IF 3.61)

  53. Pushpabai, R.R.; Carlton Ranjith W. A.; Mani, R.; Apte, D.A.; Franklin, J.B. Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus Bayani as Determined from Transcriptomic and Proteomic Analyses. Mar. Drugs 2021, 19, 202, doi:10.3390/md19040202. (IF 6.08)

  54. Sivaji, K.; Kannan, R.R.; Nandhagopal, S.; Carlton Ranjith W. A.; Saleem, S. Exogenous Human Beta Amyloid Peptide Interferes Osteogenesis through Sox9a in Embryonic Zebrafish. Mol. Biol. Rep. 2019, 46, 4975–4984, doi:10.1007/s11033-019-04948-8. (IF 2.74)

  55. Premachandran, K.; Srinivasan, T.S.; Carlton Ranjith W. A.; In Silico Approach on Sequential and Structural Variability in Oryzacystatin and Its Interaction with Cysteine Protease Enzymes of Insect. Phytochemistry 2021, 186, 112728, doi:10.1016/j.phytochem.2021.112728. (IF 4.04)

  56. Jain, R.P.; Jayaseelan, B.F.; Carlton Ranjith W. A.; Mahmoud, A.H.; Mohammed, O.B.; Ahmed Almunqedhi, B.M.; Rajaian Pushpabai, R. Mass Spectrometric Identification and Denovo Sequencing of Novel Conotoxins from Vermivorous Cone Snail (Conus Inscriptus), and Preliminary Screening of Its Venom for Biological Activities in Vitro and in Vivo. Saudi J. Biol. Sci. 2021, 28, 1582–1595, doi:10.1016/j.sjbs.2020.12.032. (IF 4.05)

  57. Rajesh, R.; Carlton Ranjith W. A.; Das, M.M.; Vanathi, G. Mass Spectrometry Based De-Novo Sequencing of Carpenter Bee Venom and Their In-Silico 3-D Structure Determination and Functional Analysis. Int. J. Infect. Dis. 2022, 116, S107–S108, doi:10.1016/j.ijid.2021.12.253. (IF 12.07-proceeding)

  58. Nagasundaram, N.; Carlton Ranjith W. A.; Samuel Gnana, P.V.; Rajaretinam, R.K. Molecular Dynamics Validation of Crizotinib Resistance to ALK Mutations (L1196M and G1269A) and Identification of Specific Inhibitors. J. Cell. Biochem. 2017, 118, 3462–3471, doi:10.1002/jcb.26004. (IF 4.48)

  59. Jabila Mary, T.R.; Kannan, R.R.; Muthamil Iniyan, A.; Carlton Ranjith W. A.; Nandhagopal, S.; Vishwakarma, V.; Prakash Vincent, S.G. β-Lactamase Inhibitory Potential of Kalafungin from Marine Streptomyces in Staphylococcus Aureus Infected Zebrafish. Microbiol. Res. 2021, 244, 126666, doi:10.1016/j.micres.2020.126666. (IF 5.07)

  60. Suraiya Saleem, R Bannerjee and Kannan RR Chrysin-Loaded Chitosan Nanoparticle-Mediated Neuroprotection in Aβ1–42-Induced Neurodegenerative Conditions in Zebrafish (2022) https://doi.org/10.1021/acschemneuro.2c00240 IF. 5.7

  61. Soundhara pandiyan N, Thanumalaya perumal S, Kannan RR. Realtime imaging and developmental biochemistry analysis during embryogenesis of Caridina pseudogracilirostris. Journal of Experimental Zoology Part A: Ecological and Integrative Physiology. 2021 Nov 15. https://doi.org/10.1002/jez.2556 IF: 2.039

  62. Saleem S, Kannan RR. Journal of Neurology and Brain Research, 2020. DOI: 10.47755/J Neuro Brain Res.2020.1.002 

  63. Nathan JR, Kurmi B, Soundharapandian N, Kannan RR. In vivo molecular validation of VEGF inhibitor extracted from marine Actinomycetes in zebrafish embryos. 2020. http://nopr.niscair.res.in/handle/123456789/54941 IF: 0.414

  64. Sivaji K, Kannan RR. Polysorbate 80 coated gold nanoparticle as a drug carrier for brain targeting in zebrafish model. Journal of Cluster Science. 2019 Jul;30(4):897-906. https://doi.org/10.1007/s10876-019-01548-1 IF: 2.78

  65. Pitchai A, Kannan RR, Freeman JL. Zebrafish as an emerging model for bioassay-guided natural product drug discovery for neurological disorders. Medicines. 2019 Jun;6(2):61. https://doi.org/10.3390/medicines6020061 IF: 1.889•   

  66. Rajesh RP, Franklin JB, Badsha I, Arjun P, Jain RP, Vignesh MS, Kannan RR. proteome based de novo sequencing of novel conotoxins from marine molluscivorous cone snail Conus amadis and neurological activities of its natural venom in zebrafish model. Protein and Peptide Letters. 2019 Nov 1;26(11):819-33. https://doi.org/10.2174/0929866526666190614144006 IF: 1.89

  67. Iniyan AM, Sudarman E, Wink J, Kannan RR, Vincent SG. Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19. The Journal of Antibiotics. 2019 Feb;72(2):99-105. https://doi.org/10.1038/s41429-018-0115-2 IF: 1.730

  68. Iniyan AM, Wink J, Landwehr W, Ramprasad EV, Sasikala C, Ramana CV, Schumann P, Spröer C, Bunk B, Joseph FJ, Joshua SA… Streptomyces marianii sp. nov., a novel marine actinomycete from southern coast of India. The Journal of Antibiotics. 2021 Jan;74(1):59-69. https://doi.org/10.1038/s41429-020-0360-z IF: 1.730

  69. García-Reyes S, Yáñez-Ocampo G, Wong-Villarreal A, Rajaretinam RK, Thavasimuthu C, Patiño R, Ortiz-Hernández ML. Partial characterization of a biosurfactant extracted from Pseudomonas sp. B0406 that enhances the solubility of pesticides. Environmental technology. 2018 Oct 18;39(20):2622-31. https://doi.org/10.1080/21622515.2017.1363295 IF: 8.49

  70. Iniyan AM, Kannan RR, Joseph FJ, Mary TR, Rajasekar M, Sumy PC, Rabel AM, Ramachandran D, Vincent SG. In vivo safety evaluation of antibacterial silver chloride nanoparticles from Streptomyces exfoliatus ICN25 in zebrafish embryos. Microbial pathogenesis. 2017 Nov 1; 112:76-82. https://doi.org/10.1016/j.micpath.2017.07.054 IF: 3.738

  71. Iniyan AM, Kannan RR, Vincent SG. Characterization of culturable actinomycetes associated with halophytic rhizosphere as potential source of antibiotics. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2017 Mar;87(1):233-42. https://doi.org/10.1007/s40011-015-0601-2 IF: 4.858

  72. Christyraj, Jackson Durairaj Selvan, Ananthaselvam Azhagesan, Mijithra Ganesan, Karthikeyan Subbiah Nadar Chelladurai, Vennila Devi Paulraj, and Johnson Retnaraj Samuel Selvan Christyraj. "Understanding the Role of the Clitellum in the Regeneration Events of the Earthworm Eudrilus eugeniae." Cells Tissues Organs 208, no. 3-4 (2019): 134-141.

  73. Subbiahanadar Chelladurai, Karthikeyan, Jackson Durairaj Selvan Christyraj, Ananthaselvam Azhagesan, Vennila Devi Paulraj, Muralidharan Jothimani, Beryl Vedha Yesudhason, Niranjan Chellathurai Vasantha et al. "Exploring the effect of UV-C radiation on earthworm and understanding its genomic integrity in the context of H2AX expression." Scientific Reports 10, no. 1 (2020): 21005.

  74. Beryl Vedha Yesudhason, Johnson Retnaraj Samuel Selvan Christyraj, Mijithra Ganesan, Karthikeyan Subbiahanadar Chelladurai, Saravanakumar Venkatachalam, Arun Ramalingam, Johnson Benedict, Vennila Devi Paulraj, and Jackson Durairaj Selvan Christyraj. "Developmental stages of zebrafish (Danio rerio) embryos and toxicological studies using foldscope microscope." Cell biology international 44, no. 10 (2020): 1968-1980. (IF-4.4)

  75. Chelladurai, Karthikeyan Subbiahanadar, Jackson Durairaj Selvan Christyraj, Kamarajan Rajagopalan, Beryl Vedha Yesudhason, Saravanakumar Venkatachalam, Manikandan Mohan, Niranjan Chellathurai Vasantha, and Johnson Retnaraj Samuel Selvan Christyraj. "Alternative to FBS in animal cell culture-An overview and future perspective." Heliyon 7, no. 8 (2021): e07686.

  76. Jebaranjitham, J. Nimita, Jackson Durairaj Selvan Christyraj, Adhimoorthy Prasannan, Kamarajan Rajagopalan, Karthikeyan Subbiahanadar Chelladurai, and Jemima Kamalapriya John Samuel Gnanaraja. "Current scenario of solid waste management techniques and challenges in Covid-19-A review." Heliyon (2022): e09855.

  77. Paul, Sayan, Subburathinam Balakrishnan, Arun Arumugaperumal, Saranya Lathakumari, Sandhya Soman Syamala, Vijithkumar Vijayan, Selvan Christyraj Jackson Durairaj, Vaithilingaraja Arumugaswami, and Sudhakar Sivasubramaniam. "Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae." Functional & Integrative Genomics 22, no. 4 (2022): 1-32.

  78. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Jemima Kamalapriya John Samuel Gnanaraja, and Johnson Retnaraj Samuel Selvan Christyraj. "Comparative analysis of the survival and regeneration potential of juvenile and matured earthworm, Eudrilus eugeniae, upon in vivo and in vitro maintenance." In Vitro Cellular & Developmental Biology-Animal 58, no. 7 (2022): 587-598.

  79. M. Rajasekar, Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus Bayani as Determined from Transcriptomic and Proteomic Analyses, Mar. Drugs, 2021, 19, 202.

  80. M. Rajasekar, Recent Trends in Rhodamine derivatives as fluorescent probes for biomaterial applications, J. Mol. Struct., 2021, 1235 130232.

  81. M. Rajasekar, Recent development in fluorescein derivatives, J. Mol. Struct., 2021, 1224, 129085

  82. M. Rajasekar, Synthesis, and characterization of hesperetin derivatives and toxicity level of the zebrafish model, Heliyon, 2021, 7, e06066

  83. M. Rajasekar, Molecular interaction of human acetylcholinesterase with trans-tephrostachin and derivatives for Alzheimer's disease, Heliyon, 2020, 6, e04930

  84. Nandhagopal S, Iniyan AM, Kannan RR, Vincent SG. In vivo evaluation of anti-MRSA compound from Streptomyces collinus ICN1 in zebrafish embryos, 2017. http://nopr.niscair.res.in/handle/123456789/42005.

  85. Ganesan, Mijithra, Johnson Retnaraj Samuel Selvan Christyraj, et al. "Live foldscope imaging of two environmentally beneficial earthworm species and their early developmental stages." Environmental Quality Management (2023).

  86. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Puja Das, Karthikeyan Mahendran, Logeshwari Nagarajan, and Saritha Gunalan. "Understanding the Multi- Functional Role of TCTP in the Regeneration Process of Earthworm, Perionyx excavatus." Tissue Engineering and Regenerative Medicine (2023): 1-14. (IF 4.5).

  87. Kandaswamy, Karthikeyan, Kayalvizhi Vadivelu, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Kamarajan Rajagopalan, Puja Das, Meikandan Chandrasekar, Nivedha B, Vijayalakshmi S, and Johnson Retnaraj Samuel Selvan Christyraj. "An improved protocol for inducing the gut cleaning process in earthworm for various experiments." Animal Biology 74, no. 3 (2024): 255-269. (IF- 1.4).

  88. Rossan Mathews, M.G., Subramaniam, R., Venkatachalam, S., Johnson Retnaraj Samuel Selvan Christyraj., et al. Biochemical and functional characterization of heat-inactivated coelomic fluid from earthworms as a potential alternative for fetal bovine serum in animal cell culture. Nature Scientific Reports 14, 5606 (2024). https://doi.org/10.1038/s41598-024-56169-0 (IF- 4.9).

  89. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, Johnson Retnaraj Samuel Selvan Christyraj, et al. "The molecular mechanisms underlying the regeneration process in the earthworm, Perionyx excavatus exhibit indications of apoptosis-induced compensatory proliferation (AICP)." In Vitro Cellular & Developmental Biology-Animal 60, no. 3 (2024): 222-235. (IF- 2.7).

  90. Subramaniam, Ravichandran, Johnson Retnaraj Samuel Selvan Christyraj, et al. "Profiling microRNAs of earthworm, Perionyx excavatus and deciphering the expression of distinct novel miRNAs regulating epimorphosis regeneration." Gene: 148636 (2024) (IF- 3.5).

  91. Rossan Mathews, Melinda Grace, Johnson Retnaraj Samuel Selvan Christyraj, et al. "De-novo transcriptome of anterior epimorphic regeneration in Perionyx excavatus." Nature Scientific Data 11, no. 1 (2024): 1093 (IF- 9.6).

  92. Don Bosco, Reiya Bosco, Johnson Retnaraj Samuel Selvan Christyraj, and Beryl Vedha Yesudhason. "Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach." Journal of Alzheimer's Disease Reports 8, no. 1 (2024): 1745-1762. (IF-2.8).

  93. Subbiahanadar Chelladurai, Karthikeyan, Jackson Durairaj Selvan Christyraj, Kamarajan Rajagopalan, Kayalvizhi Vadivelu, Meikandan Chandrasekar, Puja Das, Kalishwaralal Kalimuthu, Nivedha Balamurugan, Vijayalakshmi Subramanian, and Johnson Retnaraj Samuel Selvan Christyraj. "Ex vivo functional whole organ in biomedical research: a review." Journal of Artificial Organs (2024): 1-15. (IF-1.1).

  94. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Johnson Retnaraj Samuel Selvan Christyraj, et al. "Enhancing the wound healing potential using earthworm clitellum factors and elucidating its molecular mechanism in an in-vitro and earthworm model." Nature Scientific Reports 14, no. 1 (2024): 28086 (IF- 4.9).

  95. Rajagopalan, Kamarajan, Jackson Durairaj Selvan Christyraj, Nivetha B, Johnson Retnaraj Samuel Selvan Christyraj, et al. "Low-energy electric shock ameliorates cell proliferation, morphallaxis, and regeneration via driving key regenerative proteins in earthworm and 3T3 cells." Bioelectrochemistry 161 (2025): 108824. (IF- 4.8).

  96. Saravanakumar Venkatachalam1, Johnson Retnaraj Samuel Selvan Christyraj* et al., Exploring the fluorescence bioactive compounds in the coelomic fluid of earthworms: Insights into their structural, spectroscopic, and functional properties for biomedical applications. Journal of Oleo Science 74, no. 2 (2025): 203-220. (IF-1.7).

  97. Naveenkumar, Suresh, Subburaman Chandramohan, Johnson Retnaraj Samuel Selvan Christyraj, K. Kaviyarasu, and Azhaguchamy Muthukumaran. "Biopolymers Decorated Selenium Nanoparticle Scaffolds for Cardiac Tissue Engineering in C2C12 Cells." BioNanoScience 15, no. 1 (2025): 1-10. (IF-3.2).

  98. Ramasamy, Rajeswari, Muthukumaran Azhaguchamy, Johnson Retnaraj Samuel Selvan Christyraj, et al. "Investigating the neuroprotective properties of Sargassum wightii extract against MPP+-induced apoptosis in SH-SY5Y human neuroblastoma cells." 3 Biotech 15, no. 1 (2025): 1-9. (IF-2.6).

  99. Raveendran, R., Prabakaran, L., Senthil, R., Beryl Vedha Yesudhason., Dharmalingam, S., Sathyaraj, W.V. and Atchudan, R., 2023. Current Innovations in Intraocular Pressure Monitoring Biosensors for Diagnosis and Treatment of Glaucoma—Novel Strategies and Future Perspectives. Biosensors, 13(6), p.663. (IF-5.4).

  100. Prabakaran, L., Sathyaraj, W.V., Beryl Vedha Yesudhason., Subbaraj, G.K. and Atchudan, R., 2023. Green Synthesis of Multifunctional Silver Nanoparticles Using Plectranthus amboinicus for Sensitive Detection of Triethylamine, with Potential In Vitro Antibacterial and Anticancer Activities. Chemosensors, 11(7), p.373. (IF- 4.2).

  101. Bhoopathy, J., Vedakumari Sathyaraj, W., Beryl Vedha Yesudhason, Rajendran, S., Dharmalingam, S., Seetharaman, J., Muthu, R., Murugesan, R., Raghunandhakumar, S. and Anandasadagopan, S.K., 2024. Hemostatic potency of sodium alginate/aloe vera/sericin composite scaffolds–preparation, characterization, and evaluation. Artificial Cells Nanomedicine and Biotechnology, 52(1), pp.35-45. (IF- 5.8)

  102. Vijayakumar, S., Beryl Vedha Yesudhason., Anandharaj, J.L., Sathyaraj, W.V. and Selvan Christyraj, J.R.S., 2024. Impact of double-strand breaks induced by uv radiation on neuroinflammation and neurodegenerative disorders. Molecular Biology Reports, 51(1), p.725. (IF- 2.6)

  103. Kamarajan Rajagopalana, Jackson Durairaj Selvan Christyraj, Karthikeyan Subbiahanadar Chelladurai, et al. Understanding the molecular mechanism of regeneration through Apoptosis-Induced Compensatory Proliferation studies - Updates and Future aspects. Apoptosis (2024): 1-16. Impact Factor 7.2).

  104. Selvan Christyraj, Jackson Durairaj, Ashwin Barath Vaidhyalingham, Chandini Sengupta, Kamarajan Rajagopalan, Kayalvizhi Vadivelu. "Functional significance of earthworm clitellum in regulating the various biological aspects of cell survival and regeneration." Developmental Dynamics.

  105. Subbiahanadar Chelladurai, Karthikeyan, Jackson Durairaj Selvan Christyraj, Kamarajan Rajagopalan, and Johnson Retnaraj Samuel Selvan Christyraj. "Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening." Scientific Reports 15, no. 1 (2025): 3758.

  106. Perumal SK, Day LZ, Madan Kumar A, Chava S, Kumar V, Osna NA, Jacobs J, Rasineni K, Kharbanda KK. Lipid droplet-associated proteins in alcohol-associated fatty liver disease: A proteomic approach. Alcohol Clin Exp Res (Hoboken). 2024 Nov;48(11):2010-2021. doi: 10.1111/acer.15446. Epub 2024 Oct 16. PMID: 39414381. 

  107. Ishaniya W, Sumithaa C, Subramani M, Karanath-Anilkumar A, Munuswamy- Ramanujam G, Madan Kumar A, Rajendran S, Ganeshpandian M. Polydiacetylene/lipid-coated red-emissive silica nanorods for the sustained release and ameliorated anticancer efficacy of a Ru(arene) complex bearing piperlongumine natural product. Dalton Trans. 2024 Jan 23;53(4):1616-1629. doi: 10.1039/d3dt02940a. PMID: 38165714. 

  108. Bhalodiya SS, Parmar MP, Patel CD, Patel SG, Vala DP, Suresh N, Jayachandran B, Madan Kumar A, Narayan M, Patel HM. Acetic Acid-Driven One-Pot Synthesis of 4,7- dihydro-[1,2,3]thiadiazolo[5,4-b]pyridine-6-carboxamides and Pharmacological Evaluations. ChemMedChem. 2024 Oct 12:e202400595. doi: 10.1002/cmdc.202400595. Epub ahead of print. PMID: 39395196. 

  109. Kalaimani K, Balachandran S, Boopathy LK, Roy A, Jayachandran B, Sankaranarayanan S, Madan Kumar A*. Recent advancements in small interfering RNA based therapeutic approach on breast cancer. Eur J Pharmacol. 2024 Oct 15;981:176877. doi: 10.1016/j.ejphar.2024.176877. Epub 2024 Aug 10. PMID: 39128807. 

  110. Deeh, P.B.D., Natesh, N.S., Alagarsamy, K. Madan Kumar A, et al. Biosynthesis of silver nanoparticles using Pterorhachis zenkeri: characterization and evaluation of antioxidant, anti-apoptotic, and androgenic properties in TM3 leydig cells exposed to cyclophosphamide. ADV TRADIT MED (ADTM) (2024). https://doi.org/10.1007/s13596- 024-00792-9. 

  111. Mahalingam S, Bellamkonda R, Kharbanda KK, Madan Kumar A, Kumar V, Casey CA, Leggio L, Rasineni K. Role of ghrelin hormone in the development of alcohol-associated liver disease. Biomed Pharmacother. 2024 May;174:116595. doi: 10.1016/j.biopha.2024.116595. Epub 2024 Apr 19. PMID: 38640709.   

  112. Madan Kumar A, Gopal T, Kalari Kandy RR, Boopathy LK, Perumal SK, Ganesan M, Rasineni K, Donohue TM Jr, Osna NA, Kharbanda KK. Mitochondrial Dysfunction- Associated Mechanisms in the Development of Chronic Liver Diseases. Biology (Basel). 2023 Oct 5;12(10):1311. doi: 10.3390/biology12101311. PMID: 37887021. 

  113. Boopathy LK, Gopal T, Roy A, Kalari Kandy RR, Madan Kumar A*. Recent trends in macromolecule-conjugated hybrid quantum dots for cancer theranostic applications. RSC Adv. 2023 Jun 20;13(27):18760-18774. doi: 10.1039/d3ra02673f. PMID: 37346950 

  114. Boopathy LK, Roy A, Gopal T, Kandy RRK, Madan Kumar A*. Potential molecular mechanisms of myrtenal against colon cancer: A systematic review. J Biochem Mol Toxicol. 2024 Jan;38(1):e23525. doi: 10.1002/jbt.23525. Epub 2023 Sep 4. PMID: 37665681.  

  115. 10. Madan Kumar A, Perumal SK, Rasineni K, Donohue TM Jr, Osna NA, Kharbanda KK. Lipidomic Analysis of Liver Lipid Droplets after Chronic Alcohol Consumption with and without Betaine Supplementation. Biology (Basel). 2023 Mar 16;12(3):462. doi: 10.3390/biology12030462. PMID: 36979154. 

  116. Rajasekaran, S., Reghunath, B.S., Madan Kumar A. Facile synthesis of Mn-Ni bimetal organic framework decorated with amine as an electrode for a high-performance supercapacitor. J Solid State Electrochem 27, 911-925 (2023). https://doi.org/10.1007/s10008-023-05382-4.  

  117. Manuela G. Neuman, Madan Kumar A, Moses New-Aaron, Larisa Poluektova, Paul G. Thomas, Karuna Rasineni, Mihai Opris, Rolf Teschke. Alcohol: basic and translational research; 15th annual Charles Lieber &1st Samuel French satellite symposium. Experimental and Molecular Pathology. doi.org/10.1016/j.yexmp.2022.104750.  

  118. Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Madan Kumar A, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA and Kharbanda KK (2022) Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Front. Physiol. 13:831004. doi: 10.3389/fphys.2022.831004. 

  119. Gayathri K, Madan Kumar A*. Potential anticancer effects of cyclo(-Pro-Tyr) against N- diethyl nitrosamine induced hepatocellular carcinoma in mouse through PI3K/AKT signaling. Environmental Toxicology. 2021; 1- 14. doi:10.1002/tox.23395 

  120. Chava, Srinivas, Madan Kumar A, Matthew C. Paal, Ireland M. Murphy, Karuna Rasineni, Terrence M. Donohue Jr, Natalia A. Osna, and Kusum K. Kharbanda. Phosphatidylethanolamine Methyltransferase Deficiency Exacerbates Alcohol-Induced Liver Injury in Mice. In Hepatology, Vol. 74, Pp. 243a-243a. 111 River St, Hoboken 07030-5774, NJ USA: Wiley, 2021. 

  121. Chandrasekar, Ajith, Dayanandan Anandan, Mohana Priya Srinivasan, and Nandha Kumar Suresh. "Characterization of raw starch hydrolysing and detergent-compatible amylase from newly isolated Bacillus subtilis from bakery chimney." Biocatalysis and Biotransformation 42, no. 6 (2024): 792-806.

Contact Us

Dr. T. Sasipraba,

Vice Chancellor,

Centre for Nanoscience & Nanotechnology,

Sathyabama Institute of Science and Technology

(Deemed to be University),

Jeppiaar Nagar, Rajiv Gandhi Road, Chennai-600119,

Tamilnadu, India

Phone : +91-44-2450 3065

Fax : +91-44-2450 3814

Email: [email protected]