About the Centre

         Centre for Drug Discovery and Development was established in 2013 with the goal to explore natural resources for anti infective drug discovery with special focus on Tuberculosis and HIV. Since relocating to the Sathyabama Research Park (3rd Floor) in 2015, the Centre has broadened its research scope to encompass a wide range of disciplines such as microbial bioprospecting, infectious diseases, Anti TB and antiviral screening, Translational Immunology and vaccine development, viral proteomics, natural product chemistry, biofilm biology, seaweed research, cryosphere microbial research. Driven by both hard work and smart strategies of faculty members with the support of our management, the Centre continues to reach new heights through consistent research excellence. CDDD has been supported by prestigious funding agencies such as DST, DBT, NCPOR, ICMR, and MoES, further empowering its diverse research endeavors. The MHRD-SPARC initiative has fostered productive collaborations with international academic and research institutions, opening new avenues for global partnerships. The Centre houses two state-of-the-art BSL-II Plus facility, dedicated to the development of novel therapeutics against life-threatening diseases such as Tuberculosis, AIDS, Dengue, and chronic disorders including cancer and diabetes. CDDD also emphasizes sustainable innovation, leading to the development and patenting of eco-friendly products for societal benefit. With translational biomedicine and vaccine research at the forefront, the Centre is actively engaged in developing vaccine candidates for emerging and re-emerging viral outbreaks, contributing significantly to pandemic preparedness and global health initiatives. The Centre also organizes global health awareness programs focused on infectious diseases and public health challenges, ensuring community engagement and scientific outreach. With an accomplished team of scientists and research professionals, the Centre has achieved 225 journal publications, 65 book chapters and 7 books. The Centre’s ongoing initiatives span in-house and seed-funded projects, student research, consultancy services, invited lectures, and collaborative research programs, reflecting a vibrant and dynamic research ecosystem.

Vision

To discover new chemical entities (NCE’s), to develop Novel prophylactics, therapeutics and other high value products from natural resources to combat against life threatening infectious and non-infectious diseases.

Mission

• Bioprospecting of microbial resources from Indian rare ecosystems for anti TB, anti viral and other anti infective/ anti cancer drug discovery. 

• Protein Engineering and recombinant proteins for Biotechnological applications.

• Translational, biomedical and immunological research.

• Bioprospecting of plants and marine organisms for high value metabolites and nano materials.

• Development/standardization of biological assays and diagnostic platforms.

• Cryosphere microbial research for biotechnological applications.

• Exploring natural resources for agriculture, aquaculture, environmental and nanotechnological applications.

Thrust Areas of Research

• Diversity and bioprospecting of actinobacteria from rare habitats for sustainable health, environment, agriculture and nanotechnology

• Cryosphere Microbial Research

• Structure and Functions of Viral Proteins

• Infectious Disease Biology

• Bio-AI and Computational biology

• 3D dimensional Cell Culture Models

• Vaccine and Vaccine Delivery System Research

• Point-of-care Diagnostics Development.

• Biofilm biology and anti biofilm molecule discovery

• Bioprospecting of Seaweeds for Drug resistance Pathogens 

• Sustainable Biomaterials

• Nanocomposite- Healthcare and Immunotechnology

Centre for Drug Discovery and Development

Sathyabama Institute of Science and Technology

List of Sponsored Research projects [April 2013 – April 2025]

Expedition Projects

List of Consultancy projects [April 2013 – April 2025]

List of Seed Grant Projects 

CDDD - List of Journal Publications (2013 – April 2025)

2025

1. Benitto, J.J., Vijaya, J.J., Saravanan, T.G., M. Radhakrishnan, and Bhavesh H. Budhi  Jan 2025. Microwave-synthesized NiZrO₃@GNP and NiZrO3@MWCNT nanocomposites: enhanced antimicrobial efficacy against biofilms and Mycobacterium smegmatis. 3 Biotech 15, 35 (2025). (IF. 2.6)

2. P. Krishnamurthy, R. Shetty, and S. S. Rao, Parthasarathy, K. “Differentiation of Bacterial Species in Liquid Culture Using Laser Speckle Contrast Imaging,” J Biophotonics. 1–8, 2025, doi: 10.1002/jbio.202400565.[IF 2.0]

3. Arokiarajan, M. S., Rajasekar T., Srinivasan, N., Francis, M., Selvaraj, B., Al‐Sadoon, M. K., & Subramanian, K. (2025). Optimization of carrageenan extraction from Gracilaria edulis and determination of Its antioxidant activity. Starch‐Stärke, e70011

2024

4. Latha Srinivasan, Abinaya Gayathri, Kumaravel Kaliaperumal, Rajasekar T, Arumugam Suresh, Kumaran Subramanian, Sandhanasamy Devanesan et al., 2024 Selenium-chitosan engineered nanocomposite as efficient formulated fish diet evaluated for sustainable aquaculture practice of Oreochromis niloticus (Nile tilapia) fishes. Polymers for Advanced Technologies. https://doi.org/10.1002/pat.6436

5. Anu Varshini A M, Usha Nandini S, V Ramesh Kumar, Thangam T, Krupakar Parthasarathy. New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. 2024. NAM Journal.  Dec 2024

6. M, A., Sunkar, S., Nachiyar, C. V., & Parthasarathy, K. (2024). Computational Studies on Diospyros Ebenum and Oldenlandia Umbellata Phytochemicals as Novel Fatty Acid Synthase Inhibitors. Current Trends in Biotechnology and Pharmacy, 18(4s), 121–137. https://doi.org/10.5530/ctbp.2024.4s.10 IF 0.15]

7. Kiran Pjilip Isaac, Priya Krishnamurthy, Sujatha Narayanan Unni, Sudhanarayani S Rao, Krupakar Parthasarathy. Laser speckle Image analysis for identifying the minimum lethal concentration of ampicillin in Escherichia coli liquid cultures. 2024. Journal of Microbiological Methods. 227, December 2024, 107068 [IF: 1.7]

8. D. Lavanya, Krupakar Parthasarathy*, Haritha. S, Radhakrishnan Manikkam, Vaishnavi Chandramouli, Vignesh Sounderrajan. A database development of gas chromatographic metabolites identified in Nilavembu kudineer extracted in different solvents and comparison with previous data analysis. 2024. African Journal of Biological Sciences. [IF: 0.3]

9. Lavanya, D., Parthasarathy, K., Soytong, K., Sounderrajan, V. and Manickam, R. April 2024. Biotherapeutic intervention for dengue infection-present scenario on plant-based remedies: A review article. International Journal of Agricultural Technology 20(2):597-618

10. Ganesh Kumar Sarvesan, Krupakar Parthasarathy, Chirayu Padhiar. 2024. Designing of a Novel and Potent HPV66 L1 major Capsid protein-epitope based Therapeutic Vaccine against Human Papillomavirus (HPV): A Bioinformatics Approach. Journal of Environmental Biology, 45(2); 130-138. Mar 2024 http://doi.org/10.22438/jeb/45/2/MRN-5248

11. Priya Krishnamurthy, Sujatha Narayanan Unni, Sudha Narayani Rao, Krupakar Parthasarathy. 2024. Assessment of formation of Escherichia coli biofilm on solid substrates using Laser Speckle Imaging parameters. Biomedical Spectroscopy, Microscopy, and Imaging III 

12. Prisho Mariam Paul, Krupakar Parthasarathy, Sudhanarayani S Rao, Vignesh Sounderrajan, Swetha Sunkar. 2024. Mutational Stability Profiling and Functional Analysis of Spike Protein in Indian Sars Cov-2 Delta Variants: an in Silico Analysis.

13. Ganesh Kumar Sarvesan, Krupakar Parthasarathy, Chirayu Padhiar. 2024. Analysis of L1 Gene Sequence Variations in High-Risk and Low-Risk Human Papillomavirus (HPV) Serotypes Among Indian Women: Implications for Cervical Cancer Research. Acta Biomedica [IF: 0.5]. 

14. T. Thangam, Krupakar Parthasarathy, K. Supraja, V. Haribalaji, Vignesh Sounderrajan, Sudhanarayani S. Rao, Sakthivel Jayaraj. 2024. Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives. Tissue Engineering and Regenerative medicine [IF: 3.6]

15. Mohamed Jameer Basha Jahankir, Vignesh Sounderrajan, Sudhanarayani S. Rao, T. Thangam, Neelagandan Kamariah, Anandi Kurumbati, Shakila Harshavardhan, Archana Ashwin, Sakthivel Jeyaraj, Krupakar Parthasarathy. 2024. Accelerated mutation by host protein APOBEC in Monkeypox virus. Gene Reports [IF: 1.3]

16. Sakthivel Jayaraj, Vignesh Sounderrajan, Thangam.T, Sudhanarayani S Rao, Shakila Harshavardhan, Krupakar Parthasarathy. 2024. Genomic variants driven drug repurposing for SARS-CoV-2 using bioinformatics-based approach. Research Journal of Biotechnology [IF: 0.223]

17. Sam Ebenezer Rajadas, Vignesh Sounderrajan, Rajendran Amarnath Prabhakaran, Ragini Agrawal, Lavanya Jeyadoss, Mariappan Rajan, Krupakar Parthasarathy and Shakila Harshavardhan. June 2024. Fabrication and Functional Characterization of Chitosan-G-Poly Caprolactone Vaccine Delivery System Displaying Antigen-Antibody Immune Complexes of Mycobacterium tuberculosis. Beni-Suef University Journal of Basic and Applied Sciences 13:58. https://doi.org/10.1186/s43088-024-00520-x.

18. Anusha R, Vaishnavi C, B Abirami, Jerrine Joseph, Manigundan K, Radhakrishnan M^*, T Shanmugasundaram and K Kadirvelu. Dec 2024. Synthesis and characterization of palladium nanoparticles (PdNPs) using Punica granatum peel extracts and its evaluation for antimicrobial, antioxidant and anticancer properties Indian J Microbiology. (IF. 2.1)

19. Sangeetha, M., Sasirekha, S., Mahendran, J. Sivarajan A, Radhakrishnan M, Manigundan K, Syed Dastager, Singaravel S and R. Balagurunathan. Dec 2024. Multifunctional metabolites of Streptomyces kunmingensis BS19 from bamboo rhizosphere soil.  Int Microbiol . https://doi.org/10.1007/s10123-024-00619-2 (IF. 2.3)

20. Manigundan K., M. Radhakrishnan*, Jerrine Joseph, K. Sakthivel, A. Kishore Kumar,  Abujunaid Khan, Vinay Rajput, Syed Gulam Dastager, Mahesh S Dharne, Mohammad Umar, V. Gopikrishnan and A. Balamurugan. Aug 2024. Integrated genomic and field level evaluation of agricultural waste enriched potential Streptomyces UP1A-1 for plant growth promotion and disease control. Gene Reports. (IF. 1.0) 35(7)

21. Lokesh E, Siddharthan N, Sivarajan A, Sangeetha M, Radhakrishnan M, and Balagurunathan R. 19 July 2024. Bioactive compound from marine seagrass Streptomyces argenteolus TMA13: combatting fish pathogens with time-kill kinetics and live-dead cell imaging. Braz J Microbiol 2024 Sep;55(3):2669-2681.  doi: 10.1007/s42770-024-01407-w (IF. 2.1).

22. Radhakrishnan Manikkam*, Manigundan Kaari, Abirami Baskaran, Meganathan P. Ramakodi, Gopikrishnan Venugopal and Parli Venkateswaran Bhaskar. 11^th July 2024. Existence of rare actinobacterial forms in the Indian sector of Southern Ocean: 16S rRNA based metabarcoding study. Brazilian J Microbiology. (IF. 2.1) 55; 2363–2370

23. Prakash, M. P. K., Padmanaban, D., Loganthan, C., Palaniswamy, K., Krishnamoorthy, K., Manikkam, R., Vareeket, R. and Venugopal, G. May 2024. Investigating antagonistic activity of fish gut bacterial isolates against aquaculture pathogens: Short Communication. International Journal of Agricultural Technology 20(3):1197-1200. 

24. Eshwarnath, V. S., Thyagarajan, R., Kishorekumar, A., Gopikrishnan, V., Radhakrishnan, M*. and Song, J. J. Feb 2024. Harnessing microbial biosurfactant for agricultural applications. International Journal of Agricultural Technology 20(1):87-104.

2023

25. Kandeel, Mahmoud; Latha, S; Subramanian, Kumaran; Rennita, D; Thirunavukkarasu, Rajasekar; Ramesh, V; Srinivasan, Guru Prasad; Al-Mubarakc, Abdullah I; Chitosan/Alginate Nanocomposite with Fe Nanoparticles for the Efficient Removal of Hexavalent Chromium Pollutant. Journal of Nanomaterials; 2023 Hindawi.

26. ArokiaRajan, Mary Shamya; Rajasekar T, Mahesh F; Kumaran S, Jerrine Joseph; Anti-Tuberculosis Evaluation of Bioactive Compounds from Marine Seaweeds. Journal of Survey in Fisheries Sciences.10 4S; 817-827; 2023.

27. K, Kumaravel; S Kumaran; T Rajasekar et al., Antibacterial wound dressing with hydrogel from chitosan and polyvinyl alcohol from the red cabbage extract loaded with silver nanoparticles. Green Processing and Synthesis;12;1; 20230035; 2023.

28. Arokia Rajan, Mary Shamya; T, Rajasekar; Joseph, Jerrine et al., Identification of the Seaweed Metabolites as Potential Anti-tubercular Agents Against Human Pantothenate synthetase: An In Silico Approach; Current Microbiology;80;10;318-2023.

29. Jayanthi Palanivel, Vignesh Sounderrajan, Thangam.T, Sudhanarayani S Rao, Shakila Harshavardhan, Krupakar Parthasarathy. 2023. Latent Tuberculosis: Challenges in Diagnosis & Treatment, Perspectives, and the crucial role of Biomarkers. Current Microbiology [IF: 2.3]

30. Ganesh Kumar S, Chirayu Padhiar, Krupakar Parthasarathy. 2023. Genotypic characterization of HPV serotypes in cervical samples from Indian women: A Multi centric study. VirusDisease [IF: 0.5]

31. Prisho Mariam Paul, Sudhanarayani Rao, and Vignesh Sounderrajan, Krupakar Parthasarathy. 2023 In silico docking analysis of the FDA approved drugs on envelope protein of SARS CoV-2 Omicron variant. Biomedical and Pharmacology. [IF: 0.79]

32. Sudhanarayani S Rao, Krupakar Parthasarathy, Vignesh Sounderrajan, K. Neelagandan, Pradeep Anbazhagan, Vaishnavi Chandramouli. 2023. Animal Paper Susceptibility of SARS Coronavirus-2 infection in domestic and wild animals - A systematic review. 3 Biotech. [IF: 2.9]

33. Thenmozhli GS., Sharmila M, Radhakrishnan M*, Kishore Kumar A, Manigundan K, and Anita Pandey. Dec 2023. Distribution and anti-infective properties of culturable actinobacteria from the Indian Himalayan region (IHR). ENVIS Bulletin Himalayan Ecology. 31; 82-90.

34. Namitha, R., B. Abirami, B.S. Anoop, D.V. Diya Dominic,s Ahna Ameer, K. Manigundan, M. Radhakrishnan^*, P. Santhiya, Parli V Bhaskar, K. Govindaraju^*, I.S. Bright Singh and G. Dharani. Oct 2023. Synthesis and characterization of gold nanoparticles using Brevibacterium casei (SOSIST-06) isolated from Southern Ocean water samples and their in vitro and in silico anti-WSSV activity. Aquaculture(IF. 4.5)

35. Mohanasundaram AS, Gurnani B, Kaur K, Manikkam R. Madras eye outbreak in India: Why should we foster a better understanding of acute conjunctivitis? Indian J Ophthalmol. 2023 May;71(5):2298-2299 (IF. 2.9)

36. Ashwin R., A Aruna, K. Jisha, K. Manigundan, V. Gopikrishnan*, M. Radhakrishnan. May 2023. Exploration of fish gut associated actinobacteria for its antifouling activity. J Basic Microbiology. (IF. 2.4)

37. Radhakrishnan, M., M. Sangeetha, P. Sivasankar, K. Manigundan, Amit Kumar Sahu, Madhukar, G. Vijayalashmi, K. Sivakumar, R. Balagurunathan, S.T. Somasundaram, Syed Dastager, Luke Elizabeth Hanna and Vanaja Kumar. April 2023. Antibacterial and anti-HIV metabolites from marine Streptomyces albus MAB56 isolated from Andaman and Nicobar Islands, India. Appl Biochem and Biotechnol (IF. 3.0)

38. Mondal R, Dusthackeer V. N. A, Kannan P, Singh AK, Thiruvengadam K, Radhakrishnan, M., et al. (2023) In-vivo studies on Transitmycin, a potent Mycobacterium tuberculosis inhibitor. PLoS ONE 18(3): e0282454. (IF. 3.0)

39. Abirami B., Akshata V., Radhakrishnan M*, Namitha R, Gopikrishnan V, Govindaraju K, Manigundan K 2023. Characterization of biosynthesized gold nanoparticles from Streptomyces misionensis PYA9 with biomedical and environmental applications. International J Agricultural Technology

40. Manigundan K., Jerrine Joseph, Radhakrishnan M*., Revathy K., Anbarasu S., Sivarajan A., Sangeetha M., Amit Kumar Sahu, Madhukar Said, Syed G. Dastager and Balagurunathan R. March 2023. A Novel Finding: 2,4‑Di‑tert‑butylphenol from Streptomyces bacillaris ANS2 Effective Against Mycobacterium tuberculosis and Cancer Cell Lines. Applied Biochemistry and Biotechnology. (IF. 3.01)

41. Samuel, J., M. M. Selvam, K. Manigundan¹, Baskaran Abirami, S. Thangavel and R. K. Manikkam^*. March 2023. Biosynthesis, Characterization and Evaluation of Antimicrobial, Antioxidant and Anti-proliferative Activities of Biogenic Silver Nanoparticles Using Streptomyces KBR3. Indian J Pharmaceutical Sciences. 85(1): 23-30. (IF. 0.97)

42. Ashok Kumar, S., Karthiga, P., Rajalakshmi, G., Gopikrishnan, V., Radhakrishnan, M., Abirami, B., Manigundan, K. and Soytong, K. Jan 2023. Exploration of earthworm cast associated actinobacteria for plant growth promoting properties. International Journal of Agricultural Technology 19(1):1-8.

43. Subramani S, Varshney N, Anand MV, Soudagar MEM, Al-keridis LA, Upadhyay TK, Alshammari N, Saeed M, Subramanian K, Anbarasu K and Rohini K (2023) Cardiovascular diseases prediction by machine learning incorporation with deep learning. Front. Med. 10:1150933. doi: 10.3389/fmed.2023.1150933. (IF  5.01).

44. K Kavitha, S Bharathi, S Kumaran, M Ponmozhi, G Suresh. Exploration of phyto-beneficial traits of halophilic rhizobacteria isolated from the mangrove halophyte Avicennia marina. Archives of Phytopathology and Plant Protection. 56,18:2023; 1450-1466. (IF 1.28).

45. Srinivasan R, Rohini Karunakaran. Swarnalatha Yanamadala, Sivakumar Shanthirappan, Sidhika Kannan, Narendran Chiterasu, Kumaran Subramanian, Lamya Ahmed Al-Keridis, Tarun Kumar Upadhyay, Nawaf Alshammari. Mohd Saeed, Guru Prasad. Biological Activity of Cyclic Peptide Extracted from Sphaeranthus amaranthoides Using De Novo Sequencing Strategy by Mass Spectrometry for Cancer. Biology 2023, 12, 412. (Impact Factor: 5.16).

46. M Muthuchamy, Subramanian Kumaran, C Padhiar, DA Kumar, D Swathi. 2023. Assessment of biological properties for decellularized human umbilical cord tissue: Biomaterials in regenerative medicine. Research Journal of Biotechnology Vol 18, 7

2022

47. Mary Shamya Arokia Rajan; Rajasekar T*; Jerrine Joseph et al., Advance Research in biomedical applications on marine sulfated polysaccharide. International Journal of Biological Macromolecules (IF: 8.9) Jan 2022

48. Rajasekar T., Pandi, P., Balaraman, D. et al. Influence of extracellular protein isolated from fish gut associated bacteria as an enhancer of growth and innate immune system in Mugil cephalus. Sci Rep 12, 3217 (2022). https://doi.org/10.1038/s41598-022-05779-7 (IF: 4.39) .

49. Kumaran Subramanian, Deivasigamani Balaraman, Mani Panangal, Tentu Nageswara Rao, Elumalai Perumal, Amutha R, Alagappan Kumarappan, Pugazhvendan Sampath Renuga, Suresh Arumugam, Rajasekar T, Wilson Aruni & Suliman Yousef AlOmar Bioconversion of chitin waste through Stenotrophomonas maltophilia for production of chitin derivatives as a Seabass enrichment diet. Sci Rep 12, 4792 (2022). https://doi.org/10.1038/s41598-022-08371-1. (IF: 4.9).

50. Radhakrishnan, M, P. Krupakar, B. Abirami and D. Lavanya. 2022. Inferences of actinobacterial metabolites to combat Coronavirus. Advances in Traditional Medicine. [IF: 1.86] 

51. Manigundan; K., M. Radhakrishnan, A. Kishorekumar, and Jerrine  Joseph. 2022. Actinobacteria as a source of biofertilizer/ biocontrol agents for bioorganic agriculture. J Applied Microbiology (IF. 4.0)

52. Supriya S; Prerna DI; Santhiya P; Kannan M; Mohammed Riyaz SU; Sinouvassane Djearamane; Radhakrishnan M; Govindaraju K. 2^nd December 2022. Solid state synthesis, characterization of gold nanoparticles@thymoquinone and its molecular docking studies against virulent M. tuberculosis H37Rv strain protein and WSSV envelope protein VP28. J Materials Science and Engineering B. 288;  116187 (IF. 3.4)

53. Vaishnavi M., Abirami B., Vignesh A., Manigundan K., Gopikrishnan V.,and Radhakrishnan M*. 28^th Nov 2022. Production and characterization of glycolipid biosurfactant from Streptomyces enissocaesilis HRB1and its evaluation for biomedical and bioremediation applications. Journal of Surfactants and Detergents. (IF. 1.95)

54. Ayswarya, S., Radhakrishnan, M*., Manigundan, K., Gopikrishnan, V. and Soytong, K. Nov 2022. Antioxidant activity of 2,4-di-tert-butylphenol isolated from plant growth promoting endophytic Streptomyces KCA-1. International Journal of Agricultural Technology 18(6):2343-2352.

55. Mukhopadhyay Gangotry, Sasikumar Usha Nandhini, Ganesan Vijayalashmi, Kaari Manigundan, Baskaran Abirami, and Manikkam Radhakrishnan^*. Nov 2022. Bioactive Streptomyces sp. TFA 59 from Tripura forest soil, Northeast India. J Environmental Biology (WoS). 43; 764-770.

56. Ayswarya, S., M. Radhakrishnan* and K. Manigundan. Nov 2022. Isolation, characterization and antimicrobial activity of endophytic actinobacteria strains from medicinal plants. Indian J Pharmaceutical Science. 1150-1160. [IF. 0.97] 

57. Ayswarya Seenivasan, Radhakrishnan Manikkam^*, Manigundan Kaari, Amit Kumar Sahu, Madhukar Said and Syed G Dastager. May 2022. 2,4-di-tert-butylphenol (2,4-DTBP) from endophytic Streptomyces sp. KCA1 from Phyllanthus niruri: isolation, characterization, antibacterial and anticancer properties.  J. King Saud University – Science. 34(5). 102088 [IF. 4.0]

58. Sangeetha M, A. Sivarajan, M. Radhakrishnan and R. Balagurunathan. April 2022. Isolation and characterization of carbonic anhydrase from novel Streptomyces kunmingensis and its evaluation for biomimetic carbon sequestration. Archieves in Microbiology. [IF. 2.5]

59. Manigundan, K., M. Radhakrishnan*, and B. Abirami. April 2022. Exploring newer biosynthetic gene clusters in marine microbial prospecting. Marine Biotechnology https://doi.org/10.1007/s10126-022-10118-y [IF. 3.6]

60. Manigundan Kaari; Jerrine Joseph; Radhakrishnan Manikkam; Ayswarya Sreenivasan; Gopikrishnan Venugopal; Balamurugan Alexander; Sakthivel Krishnan. March 2022. Biocontrol Streptomyces induces resistance to bacterial wilt by increasing defense-related enzyme activity in Solanum melongena L. Current Microbiology. 79; 146 [IF. 2.1]

61. Ayswarya S, Manigundan K, Vijayalakshmi G, and Radhakrishnan M*. March 2022. Bio-prospecting of marine actinobacteria for siderophore production and antibacterial activity against multi drug resistant gram negative bacterial pathogens. J Environmental Biology. 43; 223-230 (IF. 0.78)

62. Manigundan, K., Jerrine Joseph, M. Radhakrishnan, S. Ayswarya, and Gopikrishnan, V. March 2022. Biological control of Streptomyces sp. UT4A49 to suppress tomato bacterial wilt disease and its metabolite profiling. Journal of King  Saud University  Science [IF. 4.01]

63. Sasirekha. S, M. Sangeetha, M. Radhakrishnan, Kishore Narayanan, and R. Balagurunathan R. Jan 2022. In vitro Antiproliferative Activity of Extracellular Pigment from Streptomyces sp. BS19 against T-Cell Leukemia and B Cell Lymphoblast Cell Lines. Adv. Biores., 12 (6); 13-20.

64. Manimaran,    D.,   Elangovan,    N.,    Mani,     P. Kumaran     Subramanian     et al. Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment. Sci Rep 12, 19250 (2022). https://doi.org/10.1038/s41598-022- 23386-4. (Impact Factor: 4.99).

65. Pitchiah Sivaperumal, Kannan Kamala, Kumaran Subramanian, Wilson Aruni, Baseline assessment of marine actinobacterial diversity around the nuclear power plant sites, India and its application to uranium remediation.  Rajeshkumar Shanmugam ^f, Rajendran Rajaram. Environmental Research. Volume 212, Part A, September 2022, 113135. (Impact factor: 8.43).

66. Muthuchamy M, Subramanian Kumaran, Padhiar C, Dhanraj AK, Desireddy S. Feasibility study on intact human umbilical cord Wharton’s jelly as a scaffold for human autologous chondrocyte: In-vitro study. The International Journal of Artificial Organs. 2022;45(11):936-944. doi:10.1177/03913988221118102 (Impact Factor: 1.631).

67. Ramaswamy K, Jule LT, N. N, Subramanian K, R. S, L. PD, et al. (2022) Investigation on Pollution Control Device (PCD) in iron foundry industry to reduce environmental chemicals. PLoS ONE 17(7):e0271032. https://doi.org/10.1371/journal.pone.0271032. (Impact Factor: 3.752).

68. Antonyraj Matharasi Perianaika Anahas, Subramanian Kumaran, Mahmoud Kandeel, Gangatharan Muralitharan, Jenifer Silviya, Geja Lakshmi Adhimoolam, Mani Panagal, Sampath Renuka Pugazhvendan, Gopal Suresh, A. Wilson Aruni, Senthil Rethinam, Nainangu Prasannabalaji, "Applications of Natural Violet Pigments from Halophilic Chromobacterium violaceum PDF23 for Textile Dyeing with Antimicrobial and Antioxidant Potentials", Journal of Nanomaterials, vol. 2022, Article ID 3885396, 13 pages, 2022. https://doi.org/10.1155/2022/3885396.

69. H. Jemmy Christy, Swetha Vasudevan, S. Sudha, Mahmoud Kandeel, Kumaran Subramanian, S. R. Pugazhvendan, P. Ronald Ross, Velmurugan, "Targeting Streptomyces-Derived Streptenol Derivatives against Gynecological Cancer Target PIK3CA: An In Silico Approach", BioMed Research International, vol. 2022, Article ID 6600403, 15 pages, 2022. https://doi.org/10.1155/2022/6600403.

70. Saka, A., Enkosa, E., Jule, L.T. Leta Tesfaye, Nagaprasad, N, Subramanian, Kumaran, Ramaswamy, Krishnaraj et al. Biofuel production from mango (Mangifera indica) seed extracts through zinc oxide nanoparticle. Biomass Conv. Bioref. (2022). https://doi.org/10.1007/s13399-022-03005-y. (Impact factor: 3.5).

71. Mathalaimuthu Baranitharan, Mahmoud Kandeel, Govindan Shanmugavel, Kumaravel Kaliyaperumal, Kumaran Subramanian, Kuppusamy Elumalai, Jayapal Gokulakrishnan, Hari Irrusappan, Senthil Rethinam, S. Velmurugan, "Fabrication of Silver Nanoparticles Using Fimbristylis miliacea: A Cheap and Effective Tool against Invasive Mosquito Vector, Aedes albopictus", Journal of Nanomaterials, vol. 2022, Article ID 4083663, 9 pages, 2022. https://doi.org/10.1155/2022/4083663.

72. Jule Leta Tesfaye, N . Nagaprasad, Subramanian Kumaran, R. Shanmugam, L. Priyanka Dwarampudi,Seenivasan Venkatesh. Reduction of environmental chemicals, toxicity and particulate matter in wet scrubber device to achieve zero emissions. Sci Rep 12, 9170 (2022). https://doi.org/10.1038/s41598-022-13369-w. (Impact factor: 3.8).

73. Saka Abel, Jule Leta Tesfaye, Gudata Lamessa, Shuma Soressa, Nagaprasad N, Subramanian Kumaran, Afessa Geleta, Ramaswamy Krishnaraj. Preparation of biobutanol via coffee bean harsh extracts by zinc oxide nanoparticle as catalyst. Biomass Conv. Bioref. (2022). https://doi.org/10.1007/s13399-022-02749-x. (Impact factor: 3.5).

74. Sambandam Padmanabhan, K. Giridharan, Balasubramaniam Stalin, Subramanian Kumaran, V. Kavimani, N. Nagaprasad, Leta Tesfaye Jule & Ramaswamy Krishnaraj, Energy recovery of waste plastics into diesel fuel with ethanol and ethoxy ethyl acetate additives on circular economy strategy. Sci Rep 12, 5330 (2022). https://doi.org/10.1038/s41598-022-09148-2. (Impact factor: 3.8).

75. Krishnaraj Ramaswamy, Saka Abel, JuleLeta Tesfaye, N. Nagaprasad, Kumaran Subramanian, Mahendrakumar Mani, R. Shanmugam, L. Priyanka Dwarampudi, Arpita Roy, B. Stalin. Biobutanol preparation through sugar rich Biomass by Clostridium Saccharaoper butylacenium Conversion Using Zno Nano particle Catalyst. Biomass Conv. Bioref. (2022). https://doi.org/10.1007/s13399-022-02424-1. (Impact factor: 3.5).

76. JiananSun, ValliappanKaruppiah, YaqianLi, SivakumarPandian, Subramanian Kumaran, Jie Chen. Role of cytochrome P450 genes of Trichoderma atroviride T23 on the resistance and degradation of dichlorvos. Chemosphere. Volume 290, March 2022, 133173. https://doi.org/10.1016/j.chemosphere.2021.133173. (Impact Factor: 8.1).

77. Kumaran Subramanian, Harshni Selvaraj, Balakrishnan K, Pugazhvendan Sampath Renuga, Velmurugan S, Wilson Aruni, "Anti-Quorum Sensing in Pathogenic Microbes Using Plant-Based Bioactive Phytochemicals", Advances in Materials Science and Engineering, vol. 2022, Article ID 7532086, 7 pages, 2022. https://doi.org/10.1155/2022/7532086.

78. Kumaran Subramanian, Harinakshi Logaraj, V. Ramesh, Mahendrakumar Mani, K. Balakrishnan, Harshni Selvaraj, Sampath Renuga Pugazhvendan, S. Velmurugan, Wilson Aruni, "Intelligent pH Indicative Film from Plant-Based Extract for Active Biodegradable Smart Food Packing", Journal of Nanomaterials, vol. 2022, Article ID 4482114, 8 pages, 2022. https://doi.org/10.1155/2022/4482114.

     

2021

79. Subramanian K, A M Perianaika Anahas, N Prasannabalaji, M Karthiga, S Bharathi, T Rajasekar, et al., Chitin derivatives of NAG and chitosan nano particles from marine disposal yards and their use foreconomically feasible fish feed development. 2021. Chemosphere. 130746 (Impact Factor: 5.7).

80. Stalin T, Prasad S, Parthasarathy K, Narendrakumar G, Kumar R, Samrot A, Riyaz M, Kumar G, Karthick V, Rajasekar A. 2021. In vitro antibacterial activity of biosynthesized silver nanoparticles against gram-negative bacteria. Inorganic and nano-metal chemistry. [IF: 1.716]

81. Amreen Nisa S, Vinu D, Parthasarathy K, Govindaraju K, Sharma D, Vivek R. Jellyfish venom proteins and their pharmacological potentials: A review. 2021. International Journal of Biological Macromolecules. [IF: 8.025]

82. Lavanya D, Balagurunathan R, Radhakrishnan M, Parthasarathy K. 2021. Inhibitory activity of Marine Actinobacterial Extracts against Dengue-2 Virus. Research Journal of Biotechnology. [IF: 0.454]

83. Bharathi, S., Ramesh, B., Kumaran, S. M. Radhakrishnan, D. Saravanan, P. Saravanan, .  Pugazhvendan and M. S. Nalinasundari. Nov 2021. Development of nanobiomaterial for wound healing based on silver nanoparticles loaded on chitosan hydrogel. 3 Biotech 11, 490. (IF. 2.4)

84. Manigundan, M., Jerrine Joseph,  M. Radhakrishnan, K. Revathy, S. Anbarasu, A. Sivarajan, M. Sangeetha and R. Balagurunathan^*. Nov 2021. Multifaceted bioproperties of Streptomyces bacillaris ANS2 isolated from Andaman and Nicobar Islands, India. Res J Biotechnology. 16(11); 99-108. 

85. Sasirekha S., Jerrine Joseph, Radhakrishnan M, Kishore Narayanan and Balagurunathan R. Sep 2021.  In Silico Docking Analysis of Marine Actinobacteria Derived Antibiotic, Grincamycin against the Epigenetic Enzyme Coactivator-Associated Arginine Methyltransferase1 (CARM1).  Adv. Biores., 12 (5): 13-16.

86. Vignesh A., Gopikrishnan V*, Anbarasu S., Radhakrishnan M., and Jerrine Joseph. Oct 2021. Biomedical applications of fish gut associated Streptomyces maritimus IM20 isolated from Rastrelliger kanagurta (Indian mackerel). Research J Biotechnology. 16(10); 120-130.

87. Sasidhar, M., M. Masilamaniselvam, B. Abirami, K. Manigundan, M. Radhakrishnan*. Oct 2021. Antifungal activity of actinobacteria LA34 isolated from forest soil. Research J Biotechnology. 16(10); 92-101.

88. Kaari, M., Joseph, J., Radhakrishnan M., Venugopal, G., and Soytong, K. Sep 2021. Streptomyces mediated stimulation of defense related enzymes to increase the biocontrol resistance in Capsicum annuum L. against Ralstonia solanacearum. International Journal of Agricultural Technology 2021Vol. 17(5):1779-1792.

89. Gopikrishnan, V., Radhakrishnan, M., Joseph, J., Abirami, B. and Manigundan, K. Sep 2021. Phytomicrobiome: A potential resource for agriculture – Short Review. International Journal of Agricultural Technology 2021Vol. 17(5):1727-1734.

90. Balakrishnan, M. Radhakrishnan, V. Gopikrishnan and R. Balagurunathan. August 2021. Evaluation of rhizosphere Streptomyces for zinc solubilizing and plant growth promoting properties. Research J Biotechnology. 16(9); 36-47. (Scopus and Web of Science) 

91. Abirami B., Manigundan K., Venugopal G., Radhakrishnan M.,* Jerrine Joseph and Parli V Bhaskar. Aug 2021. Anti freeze proteins (AFP): properties, sources and applications. International Journal of Biological Macromolecules. 189; 292-305.(IF. 8.0)

92. Manigundan K., Jerrine Joseph., Radhakrishnan M., Ayswarya S., Gopikrishnan V., Balamurugan A., Sakthivel K. July 2021. Antibiofilm and biocontrol potential of Streptomyces cultures against Ralstonia solanacearum on tomato plants Indian J Microbiology.  IF. 2.4

93. Pooja Rao, Yasaswini Winchester, Ramesh kumar Varatharajan, Venugopal Gopikrishnan, Manikkam Radhakrishnan*, July 2021. Bioprospecting of insect nest associated actinobacteria with special reference to antimicrobial and anti HIV activity. Res J Biotechnology (Web of Science)

94. Yogesh Pradeep, L., Masilamani Selvam, M., Manigundan, K., Gopikrishnan, V., Radhakrishnan, M., Jerrine, J. and Soytong, K. July 2021. Evaluation of the antagonistic and plant growth promoting properties of Streptomyces isolated from aubergine rhizosphere soil of Kanchipuram, Tamil Nadu, India. International Journal of Agricultural Technology 17(4):1651- 1664.[Scopus]

95. Abirami Baskaran, Radhakrishnan Manikkam, Kumaran Subramanian, and Aruni Wilson. June 2021.. Impacts of global warming on marine microbial communities. Science of the Total Environment. 791; 147905 [IF.10.63] [Scopus & WoS]

96. Mahasree, V., V. Gopikrishnan., A. Vignesh, M. Radhakrishnan, Jerrine Joseph and Wilson Aruni. June 2021. Exploration of Fish Gut Associated Actinobacteria for its Anti-Microbial and Anti-Quorum Sensing Properties. Advances in Biological Science Research. 13; 126-139.

97. Gopikrishnan, V., Radhakrishnan, M., Joseph, J., Abirami, B., Manigundan, K., Suresh, A. and Soytong, K. April 2021. A novel of bioprospecting of earthworm cast associated actinobacteria for its antimicrobial properties. International Journal of Agricultural Technology 17(2):497-502. [Scopus]

98. Revathy K., M. Radhakrishnan* and S. Anbarasu. Mar 2021. Activity and toxicity assessment of partially purified bacteriocin from Lactic Acid Bacteria against Mycobacterium kansasii. Annals of R.S.C.B., 25(1); 6715 – 6721.  [Scopus]

99. Balakrishnan, K. J. Thirumalai Raj, M. Radhakrishnan, V. Gopikrishnan and R. Balagurunathan. Feb 2021. Phosphate solubilization and plant growth promoting actinobacteria from rhizosphere soil. Indian Journal of Agricultural Research. 55(1); 87-92. (Scopus) 

100. Radhakrishnan Manikkam*, Vijayalakshmi Ganesan, Gopikrishnan Venugopal, Suresh Arumugam, Manigundan Kaari, Jerrine Joseph. Jan 2021. Bioprospecting of actinobacteria from selected mangrove ecosystems, India effective against carbapenem resistant Klebsiella pneumoniae ATCC BAA-1705. Journal of Applied Pharmaceutical Science. 11(1); 89-94. [Scopus] 

101. Vaishali, R, Ruchi Pathak, Subhashini D., Vignesh A., Manigundan K., Gopikrishnan V., Revathy K. Anbarasu S., Radhakrishnan M. and Jerrine Joseph. Jan 2021. Antibacterial, antitubercular and anticancer activity of gut-associated Streptomyces enissoceasilis SFA isolated from marine fish Carcharhinus amblyrhynchos. Research J Biotechnology. 16(1); 9-16. (Web of Science)

102. Lavanya, D., M. Radhakrishnan and P. Krupakar. Jan 2021. Inhibitory activity of marine actinobacterial extracts against Dengue-2 virus. Research J Biotechnology. 16(1); 120-128. (Web of Science)

103. Nekkanti Deepa Sudeeshna, Sasikumar Ushanandhini, Baskaran Abirami, Kaari Manigundan, Venugopal Gopikrishnan and Manikkam Radhakrishnan*. Mar 2021. Antimycobacterial properties and metabolite profiling of fish gut associated Streptomyces sp. MCA2. Biomedical Biotechnology Research Journal. 5(1); 88-99. 

104. Bharathi Kumar, Siva Vijayakumar Tharumasivam, Vasuki Boominathan, Elumalai Perumal, Prabu Dhandapani, Kumaravel Kaliyaperumal, Suresh Arumugam, Kumaran Subramanian, Pugazhvendan Sampath Renuga, Vasanth Shakthivel, Bupesh Giridharan, Wilson Aruni, Lokesh Kumar Boopathy, "A Pilot Study on Nanotherapy of Momordica charantia against Trimethyltin Chloride-Induced Neurotoxicity in Danio rerio (Zebrafish)", Journal of Nanomaterials, vol. 2021, Article ID 2180638, 12 pages, 2021. https://doi.org/10.1155/2021/2180638.

105. Valliappan Karuppiah, Lu Zhixian, Hongyi Liu, Vallikkannu Murugappan, Subramanian Kumaran, Anthonyraj Matharasi Perianaika Anahas, Jie Chen. Co- cultivation of T. asperellum GDFS1009 and B. amyloliquefaciens 1841: Strategy to regulate the production of ligno-cellulolytic enzymes for the lignocellulose biomass degradation. Journal of Environmental Management 301 (2022) 113833. https://doi.org/10.1016/j.jenvman.2021.113833. (Impact factor: 9.9)

106. Panneerselvam Saravanan, Subramanian Kumaran, Selvaraj Bharathi, Padmanaban Sivakumar, Padian Sivakumar, Sampath Renuka Pugahvendan, Wilson Aruni, Sahadevan Renganathan^. Bioremediation of Synthetic Textile Dyes Using Live Yeast Pichia pastoris. Environmental Technology & Innovation. 2021, 101442 (Impact Factor:9.96).

2020

107. Mary Shmaya A., Thriunavukkarasu, R*., Joseph, J., & Aruni, W. (2020). Effect of seaweed on seed germination and biochemical constituents of Capsicum annuum. Biocatalysis and Agricultural Biotechnology, 29, 101761.

108. Kumaran. S, S. Bharathi, Uttra. V, Rajasekar T, Gopi .V, Prasannabalaji. N, Pugazhvendan. S.R, Wilson Auni, Deivasigamani. B. OCT 2020. Bioactive metabolites produced from Streptomyces enissocaesilis SSASC10 against fish pathogens Biocatalysis and Agricultural Biotechnology.1716:42:00.Scopus/Web of Science

109. Kumaran Subramanian, Balamurugan S, Wilson Aruni, Alagappan Kumarappan, Rajasekar T, Guru Prasad Srinivasan, Selvaraj Bi, Prasannabalaji, Pugazhvendan Sampath Renuga, Anandajothi Elamaran, Deivasigamani Balaraman & Mahendran Subramanian. July 2020.  Bioconversion of chitin and concomitant production of chitinase and N-acetylglucosamine by novel Achromobacter xylosoxidans isolated from shrimp waste disposal area. Nature Scientific Reports. 208:18:00. (IF:  4.1).Scopu/Web of Science

110. Subramanian Kumaran, Anahas Perianaika Matharasi Antonyraj, Prasannabalaji Nainangu, Pugazhvendan Sampath Renuka, Rajasekar Thirunavukarasu, Sadaiappan Balamurugan, Bharathi Selvaraj, Suresh Gopal, Guru Prasad Srinivasan, Praveen Kumar Elango, Balasubramaniyan Balakrishnan and Wilson Aruni. July 2020. A review on pathogenesis, prevention and control of novel Corona virus of Covid-19. Oriental Journal of Chemistry. 36,( 4). (IF 0.136).Web of Science

111. Jerrine Joseph, R. Devadarshini, A. Suresh, M. Radhakrishnan , T. Rajasekar, V. Gopikrishnan, S. Shakila* and Wilson Aruni. June 2020. Antiseptic efficacy of combination of essential oils against multidrug-resistant pathogens. Biosci Biotech Res Commun. 13 (2); 565-570. Web of Science

112. T. Rajasekar, K. Karthika, G. Muralitharan, A. Mary Shamya, S. Sabarika, S. Anbarasu, K. Revathy, N. Prasannabalaji and S. Kumaran.May 2020. Green synthesis of gold nanoparticles using extracellular metabolites of fish gut microbes and their antimicrobial properties Brazilian Journal of Microbiology. 2020; 51(3):957-967. (IF 2.8).Web of Science

113. Raghavi R, Mohamoodha N,, Cholapandian K,, Rajasekar T, Wilson Aruni and Jerrine Joseph*. March 2020. In-vitro anti-inflammatory and in-silico anti- aging properties of Psidiumguajava Leaves. Biosc.Biotech.Res.Comm. Vol 13 (1) - March 00-00 2020.Web of Science

114. Kumaran S, Wilson Aruni, Karthika M, Prasanna Balaji N, Pugazhvendan S.R, Bharathi S, Rajasekar T & Guru Prasad .S February 2020. Trends in aquaculture feed development: from Chitosan Nano particle with N-Acetyle-D-Glucosamine (NAG) for disease control – A review. Bioscience Biotechnology Research Communications.13 (1) 00-00 2020.Web of Science

115. Hotra A, Ragunathan P, Ng PS, Seankongsuk P, Harikishore A, Sarathy JP, Saw WG, Lakshmanan U, Sae-Lao P, Kalia NP, Shin J, Kalyanasundaram R,  Sivaraj A, Parthasarathy K, Pradeep CN, Makhija H, Dröge P, Poulsen A, Tan JHL, Pethe K, Dick T, Bates RW, Grüber G. 2020. Discovery of a novel Mycobacterial F-ATP synthase inhibitor and its potency in combination with diarylquinolines. 2020. Angewandte Chemie - International Edition. [IF: 16.82]

116. Sivaraj A, Vanaja K, Revathy S, Parthasarathy K, Govindaraju K. 2020. Commercial Yeast Extracts Mediated Green Synthesis of Silver Chloride Nanoparticles and their Anti-mycobacterial Activity. Journal of Cluster Science. [IF: 3.061]

117. Govindaraju K, Vijai Anand K, Sivaraj A,  Theerthagiri J, Revathy S, Parthasarathy K, Durai G, Kannan M, Subramanian KS. 2020. Seaweed (Turbinaria ornata)-assisted green synthesis of magnesium hydroxide [Mg(OH)2] nanomaterials and their anti-mycobacterial activity. Materials Chemistry and Physics. [IF: 4.094]

118. Annadurai, A., Elakia, V. Gopikrishnan, Jerrine Joseph and M. Radhakrishnan. Dec 2020. Anticorrosive performance of Phyllanthus aamarus and Senna auriculata extract-based hybrid coating on steel. Indian J Environmental Protection. 40(12); 1273-1279. (Scopus)

119. Vaishnavi, M., K. Manigundan, Thania smalia, V. Gopikrishnan, Ashok Kumar, Luke Elizabeth Hanna, S. Ushanandhini, and M. Radhakrishnan* and Wilson Aruni. Dec 2020. Antimicrobial and anti HIV activity of extracellular pigment from Streptomyces sp. S45 isolated from forest soil, Sabarimala,  Kerala, India. Indian Journal of Experimental Biology. 58; 861-868. (IF. 0.80) (Scopus & Web of Science)

120. Namitha, R., R. Vasantharaja, M. Radhakrishnan, and K. Govindaraju. October 2020. Actinobacteria and their bioactive molecules for anti-WSSV activity: A mini review. Aquaculture Research. 00:1–7. (IF 2.4) 

121. Chandrakumar, D., K. Gopalakrishnan_, V. Karuppiah, N. Rajendra Prasad, M. Radhakrishnan*, K. Sivakumar, and R. Balagurunathan. September 2020. Novel strain of Nocardiopsis sp. CN2 from Andaman Nicobar Islands: Isolation, taxonomy, fermentation and antiproliferative effect on cervical cancer cells. Biomedical and Biotechnology Research Journal. 

122. Ashok Alka, Sasi Kumar Usha Nandhini, Sreenivasan Ayswarya, Kaari Manigundan, Kalyanasundaram Revathy and Manikkam Radhakrishnan^*. June 2020. Anti-mycobacterial activity of endophytic actinobacteria from selected medicinal plants. Biomedical Biotechnology Reserch Journal (BBRJ)  

123. Ayswarya, S., G. Vijayalashmi, A. Vignesh, K. Manigundan, V. Gopikrishnan, S. Anbarasu, Jerrine Joseph, and M. Radhakrishnan*. September 2020. Antimicrobial and antitubercular activity of endophytic actinobacterium, Streptomyces sp. SACC 4 isolated from the mangrove plant Rhizophora apiculata. Bioscience Biotechnology Research Communications. 13 (3); July-Aug-Sep 2020: 1050-1054 (Web of Science)

124. Anbarasu Sivaraj, Revathy Sundar, Krupakar Parthasarathy, Jerrine Joseph, Vanaja Kumar and Radhakrishnan Manikkam. September 2020. Luciferase Reporter Phage (LRP) assay for anti TB screening: Current status and challenges. Biosci Biotech Res Commun., 13 (3); July-Aug-Sep 2020: 1236-1244 (Web of Science)

125. Revathy Kalyanasundaram, Manikkam Radhakrishnan* and Sivaraj Anbarasu. September 2020. Evaluation of inhibitory activity of bacteriocins from Enterococcus italicus BLN48 against Mycobacterium fortuitum and its toxicity profiling. Biosci. Biotech.Res. Commun., 13 (3); July-Aug-Sep 2020: 1156-1161 (Web of Science)

126. Manigundan, K., Joseph, J., Ayswarya, S., Vignesh, A., Vijayalakshmi, G., Soytong, K., Gopikrishnan, V. and Radhakrishnan, M. September 2020. Identification of biostimulant and microbicide compounds from Streptomyces sp. UC1A-3 for plant growth promotion and disease control. International Journal of Agricultural Technology. 16(5):xxx 

127. Sivaraj Anbarasu, Vanaja Kumar, Uma Rani, Revathy Kalyanasundram and Manikkam Radhakrishnan. April 2020. Purification and characterization of bacteriocins active against Mycobacterium tuberculosis from lactic acid bacteria. Res. J. Biotechnology. 15(4); 74-81. 

128. Vaishnavi C., R. Anusha, M. Radhakrishnan, S. Anbarasu,  Wilson Aruni and Jerrine Joseph. April 2020. In vitro activity of selected medicinal plant extracts against Mycobacterium tuberculosis and other Non Mycobacterial Pathogen. Biosci. Biotech. Res. Comm. 13(1)

129. Sukanthkumar Ezhakil, Vijayalakshmi Ganesan, Manigundan Kari, Bharathi Selvaraj, Gopikrishnan Venugopal, Jerrine Joseph, Radhakrishnan Manikkam*. Aug 2020. Anti infective potential of marine actinobacteria against carbapenem resistant Klebsiella pneumoniae ATCC13882. Research J. Pharm. and Tech. 13(8):3653-3660.

130. Vignesh. A, Manigundan. K, Santhosh kumar. J, Shanmugasundaram, T, Gopikrishnan. V, Radhakrishnan. M*, Jerrine Joseph, Ayyasamy. P.M, Govindaraj Dev Kumar, PR Meganathan and Balagurunathan, R. Aug 2020. Microbial degradation, spectral analysis and toxicological assessment of malachite green dye by newly isolated actinobacterium, Streptomyces chrestomyceticus (S20). Bioprocess and Biosystems Engineering.  [IF 3.1]

131. Gurugnana Soundarya, Manigundan Kaari, Meganathan P. Ramakodi, Balaji Subramanyam and Radhakrishnan Manikkam*. Jan 2020. Antimicrobial and anti-tubercular potential of Streptomyces species isolated from a Northern State of India, Himachal Pradesh. J Environmental Biology. 41(1); 131-138. [IF 0.7] 

132. Sadaiappan Balamurugan, Kannan Sivakumar, Palanisamy Sivasankar, Manikkam 
     Radhakrishnan, Ramasamy Balagurunathan, N Anilkumar, Mahendran Subramanian. 2020.  Microbial diversity and its predicted metabolic functions in the 
     Southern Ocean (Antarctic). Data in Brief. 28; 104876. 

133. Radhakrishnan Manikkam*, Madangchanok Imchen_, Manigundan Kaari, Vignesh Angamuthu, Venugopal Gopikrishnan, Thangavel Shanmugasundaram, Jerrine Joseph, Ramasamy Balaguruanthan and Ranjith Kumavath. Feb 2020. Metagenomic insights unveil the dominance of undescribed actinobacteria in pond ecosystem of an Indian Shrine. Metagene. 23; 100639.

134. Devagi, P., T. Chitrikha, R.V. Sandhiya, M. Sairandhry, S. Bharathi, P. Velmurugan, M. Radhakrishnan, T. Sathiamoorthi and G. Suresh. Feb 2020. Actinobaterial-mediated fabrication of silver nanoparticles and their broad spectrum antibacterial activity against clinical pathogens. Journal of Nanoscience and Nanotechnology. 20; 2902-2910. (IF. 1.34)

135. Seenivasan, Gopikrishnan Venugopal, Radhakrishnan Manikkam, Balagurunathan Ramasamy and Aruni Wilson. April 2020. A multifunctional Streptomyces maritimus SACC-152 isolated from Andaman and Nicobar Islands, India. Asian Journal of Biomedical and Pharmaceutical Sciences. 10(71); 10-19.

136. Tentu Nageswara Rao, A.P.B. Balaji, Mani Panagal, Botsa Parvatamma, Bharathi Selvaraj, Saravanan Panneerselvam, Wilson Aruni, Kumaran Subramanian, Pugazhvendan Sampath Renuga, Sivakumar Pandian. Nanoremediation of dimethomorph in water samples using magnesium aluminate nanoparticles. Environmental Technology & Innovation 20 (2020) 101176. (ImpactFactor: 7.958).

137. Zhenjiang Li, Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni, Srinivasa Rao Bolla, Sulaiman Alharbi, Hariprasath Lakshmanan, Kumaran Subramanian, Aruni Wilson, Aref Ali Mohammed Aladresi, Omar H. M. Shair. Apoptotic induction and antimetastatic activity of eugenol encapsulated chitosan nanopolymer on rat glioma C6 cells via alleviating the MMP signaling pathway. Journal of photo chemistry and Photobiology B: Biology. 2020. Volume 203- 111773. (Impact Factor :4.25).

138. Prasanna Balaji Niangua, Anahas Perianaika Matharasi Antonyraj, Kumaran Subramanian, Sowparthani Kaliyaperumal, Suresh Gopal, Pugazhvendan Sampath Renuka, Wilson Aruni. In vitro screening of antimicrobial, antioxidant, cytotoxic activities, and characterization of bioactive substances from freshwater cyanobacteria Oscillatoria sp. SSCM01 and Phormidium sp. SSCM02. Biocatalysis and Agricultural Biotechnology. (2020) 29:101772. .(Impact factor:3.4).

139. Gopal Suresh, Dhanasegaran Kokila, Thirunavukarasu Chitrikha Suresh, Subramanian Kumaran, Palanivel Velmurugan, Kaliyappan Amballandi Vedhanayakisri, Subpiramaniyam Sivakumar, Arumugam Veera Ravi. Mycosynthesis of anticancer drug taxol by Aspergillus oryzae, an endophyte of Tarenna asiatica, characterization, and its activity against a human lung cancer cell line. Biocatalysis and Agricultural Biotechnology, 2020. Volume 24, March 2020,101525. .(Impact factor:3.4).

140. S Bharathi, S Kumaran, G Suresh, M Ramesh, V Thangamani, SR PughazhventhanExtracellular synthesis of nanoselenium from fresh water bacteria Bacillus sp., and its validation ofantibacterial and cytotoxic potential. Biocatalysis and Agricultural Biotechnology, 2020. Volume 27, August 2020,101655. .(Impact factor:3.4).

141. Rajeswari M.V, Annamalai N, Kumaran S, Wilson Aruni, Balasubramanian T. Effect of Probiotic Strain Bacillus firmus CAS 7 As Feed Supplement for Growth, Survival and Colour Enhancement of Smoke Angelfish Apolemichthys xanthurus. Biosc.Biotech.Res.Comm. 2020;13(1).

      

2019

142. Santhiyaa RV, Wilson Aruni A, Suresh G, PrasannaBalaji N, Barathi S, Pugazhvendan SR, Rajasekar T, Karthikeyan DR and KumaranS. December 2019. Applications of feather keratin hydrolyzate in divergent field. Biosc.Biotech.Res.Comm 12 (4) 00-00.Web of science

143. Rajasekar T*, Shamya AM and JoesphJ. Screening of phytochemical, antioxidant activity and anti-bacterial activity of marine seaweeds. International Journal of Pharmacy and Pharmaceutical Sciences.2019 11(1); 61-66.

144. Mary Shamya A., T. Rajasekar R. Rengasamy. Carbon sequestration potential of Scenedesmus quadricauda (Turpin) and evaluation on Zebra fish (Daniorerio). Aquaculture Reports13, 100178 (March 2019) (IF.1.15).

145. Dhanalashmi R., K. Menaka, Annam Rennita, V. Gopikrishnan, T. Shanmugasundaram, Jerrine Joseph and M. Radhakrishnan*. 2019. Bioleaching of heavy metals from printed circuit board (PCB) by novel Streptomyces sampsonii TN10 isolated from insect nest. Bioresources and Bioprocessing. 6; 47. 

146. Gopikrishnan, V., M. Radhakrishnan, T. Shanmugasundaram, and R. Balagurunathan. Sep 2019. Isolation, characterization and antifouling activity of taxifolin from Streptomyces sampsonii PM33 isolated from mangrove ecosystem, South India. Nature Scientific Reports. 9; 12975. [IF. 4.5]

147. Sivarajan, A., T. Shanmugasundaram,  M. Sangeetha, M. Radhakrishnan and R. Balagurunathan.  Aug 2019. Screening, production and characterization of biologically active secondary metabolite(s) from marine Streptomyces sp. PA9 for antimicrobial, antioxidant and mosquito larvicidal activity. Indian Journal of Geo Marine Sciences. 48(8); 1319-1326. [IF. 0.35]

148. Manisha Mohandas, Mithali Jain, G. Vijayalakshmi, V. Gopikrishnan, M. Masilamani selvam and M. Radhakrishnan. Aug 2019. Bioprospecting of actinobacteria from Andaman marine ecosystem: Isolation, antagonistic potential and taxonomy of potential strain Indian Journal of Geo Marine Sciences. 48(8);1312-1318. [IF. 0.35] 

149. Manigundan. K, Revathy Sundar, Sivarajan, S. Anbarasu, Jerrine Joseph, M. Radhakrishnan and R. Balagurunathan. Aug 2019. Bioactive potential of selected actinobacterial strains from Andaman marine ecosystems effective against Mycobacterium tuberculosis and other clinical pathogens. Indian Journal of Geo Marine Sciences. 48(8); 1307-1311. [ IF. 0.35] 

150. Vignesh. A, Ayswarya. S, Gopikrishnan, V. and Radhakrishnan, M. Aug 2019. Bioactive potential of fish gut associated actinobacteria isolated from marine fishes. Indian Journal of Geo Marine Sciences. 48(8);1280-1285. [IF. 0.35] 

151. Revathy K., Radhakrishnan Manikkam* and Sivaraj Anbarasu. 2019. Isolation, characterization of Lactic Acid Bacteria from cow and buffalo milk and evaluation for antibacterial and antimycobacterial activity in vitro. Asian J Microbiology Biotechnology and Environmental Sciences. 21(4); 1041-1046.

152. Sangeetha, M., B. Surya, A. Sivarajan, M. Radhakrishnan, J. Jerrine and R. Balagurunathan. Nov 2019. Bioelectricity generation from industrial effluent through actinobacterial fuel cells. Pollution Research S77-S83.

153. Sangeetha, M., A. Sivarajan, M. Radhakrishnan and R. Balagurunathan. Aug 2019. Influence of magnesite mine soil for enhancement the efficiency of bioactive compound production from Actinobacteria. Drug Invention Today. 12(8); 1614-1619.

154. Sheela Rani B., Jerrine Joseph, Radhakrishnan Manikkam and Manigundan Kaari. Jan 2019. Applications and Opportunities of Nanorobotics in Biopharmaceutical and Biomedical Sciences Research Journal of Pharmaceutical, Biological and Chemical Sciences, 10(1);1114-1120.

155. Jinmei Yang, Qiang Wang, Chunxiao Wang, Ruiyi Yang, Mukhtar Ahmed, Subramanian Kumaran, Periyannan Velu & Bo Li. Pseudomonas aeruginosa synthesized silver nanoparticles inhibit cell proliferation and induce ROS mediated apoptosis in thyroid cancer cell line (TPC1). Artificial Cells, Nanomedicine, And Biotechnology. 2019, vol. 48, no. 1, 800–809. (Impact Factor:6.355).

2018

156. Dinesh G, Suresh G, Bharathi S, Kotteswaran S, AnanthaJ othi E, Pugazhvendan SR, Rajasekar T, Kumaran S. Isolation and characterization of feather degrading bacteria from poultry waste.IJRAR .2018: 5(4); 334-340.(Oct 2018).

157. Anbarasu S, Revathy S, Manigundan K, Rajasekar T, Mary Shamya, Jerrine Joseph. Evaluating the Anti-mycobacterial Activity of Nigella sativa Seed Extracts. Der Pharmacia Lettre, 2018, 10 [7]: 1-9 (2018).

158. T. Shanmugasundaram, M. Radhakrishnan, A. Poongodi, R. Balagurunathan. Jan 2018. Enhanced anticancer activity of biosynthesised superparamagnetic magnetite (Fe₃O₄) nanoparticles on HeLa cell lines: An in vitro study.  MRS Communications. [IF. 2.9] 

159. Sivaraj Anbarasu, Revathy Sundar, Radhakrishnan Manikkam, Krupakar Parthasarathy, Vanaja Kumar. August 2018. Potential Applications of Lactic Acid Bacteria and Bacteriocins in Antimycobacterial Therapy- Mini Review. Asia Pacific Journal of Tropical Medicine. 11(8); 453-459.

160. Radhakrishnan Manikkam and Jerrine Joseph. 2016. In silico docking analysis of actinobacterial sideromycins with the alanine racemase enzyme of Acinetobacter baumanii. Journal of Computational biology and bioinformatics.

161. Saravanan, D, M. Radhakrishnan and R. Balagurunathan. 2016. Isolation of plant growth promoting substance producing bacteria from Niligiri hills with special reference to Phosphatase enzyme. Journal of Chemical and Pharmaceutical Research, 2016, 8(1):698-703 

162. Saravanan, D., and M. Radhakrishnan. 2016. Antimicrobial activity of mangrove leaves against drug resistant pathogens. International Journal of PharmTech Research, 9(1); 141-146.

163. Saravanan. D., and M. Radhakrishnan. 2016. Antimicrobial activity of pigments produced by fungi from Western Ghats. Journal of Chemical and Pharmaceutical Research, 8(1):634-638. 

2017

164. Rajasekar T*, Shamya AM and Joesph J. Zebra Fish in Tuberculosis Research. Virol Immunol J 2017, 1(5): 000129.

165. Avila Josephine.B, Mary Teresita.V, Ashwini Anantharaman, Rajasekar.T, Jerrine Joesph. synthesis and characterisation of cu (ii) schiff base complex derived from amoxicillin trihydrate and vanillin for antimicrobial application. Int J Pharma Bio Sci 2017 October; 8(4): (P) 224-231

166. Jerrine J*, Tahseen A,, Rajasekar T, Radhakrishnan M, Manigundan K, Swarnalatha L Anbarasu S. Antioxidant and Anticancer Potential of Nigella sativa Seeds. Der PharmaChemica, 2017, 9(22): 106-111 (Dec 2017)

167. Shanmugasundaram, T., M. Radhakrishnan, V. Gopikrishnan and Kathirvelu, R. Balagurunathan. November 2017.  In vitro antimicrobial and in vivo wound healing effect of actinobacterially synthesised silver, gold and silver/gold nanoparticles. RSC Advances. 7: 51729 –51743 [IF 4.0]

168. Shanmugasundaram, T., M. Radhakrishnan, V. Gopikrishnan and R. Balagurunathan. October 2017. Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: An in vitro and in vivo perspectives. Nanoscale [IF 8.3). 

169. Venugopal Gopikrishnan, Manikkam Radhakrishnan_,Raasaiyah Pazhanimurugan, Thangavel Shanmugasundaram and Ramasamy Balagurunathan. July 2017. Antimicrobial, Antiuberculosis and Antiproliferative activity of Quercetin isolated from marine Streptomyces fradiae PE7. Bangladesh J Pharmacology. 12; 333-334. [IF: 1.1] 

2016

170. Rajasekar, T., Anbarasu, S., Radhakrishnan, M., Jerrine, J.* and Vanaja. K. In vitro antitubercular activity of Tridax procumbens extracts against whole cell Mycobacterium tuberculosis and its lysine amino transferase., Bangladesh Journal of Pharmacology. 2016; 11: 190-191.

171. Helen Mary L, Florida Tilton, Jerrine Joseph*, Sudarsanam D, Anitha CP  , Suresh A, Rajasekar T, Ravisankar N and M. Muthuswamy. DNA Barcoding for Molecular Characterization of A Medicinal Plant – Citrullus Colocynthis. Der Pharmacia Lettre. 2016. 8 (4):304-309.

172. Ravisankar N, Jerrine J, Radhakrishana M, Rajasekar T.2016In vitro cytotoxicity of methanol extracts of Hypericum wightianum and Hypericum hookerianuim against 3T3L1 cell lines. Bangladesh J Pharmacol.2016; 11:328-29.

173. Uma Suganya KS, Govindaraju K, Ganesh Kumara V, Karthick V, Parthasarathy K. 2016. Pectin mediated gold nanoparticles induces apoptosis in mammary adenocarcinoma cell lines. International Journal of Biological Macromolecules. [IF: 8.025]

174. Parthasarathy K, Sivaraj A, Sundar R. 2016. Identification of new efflux pump proteins from multidrug resistant Mycobacterium tuberculosis and screening for peptide-based efflux pump inhibitors. International Journal of Infectious Diseases. [IF: 12.074]

175. Raasaiyah Pazhanimurugan, Manikkam Radhakrishnan, Thangavel Shanmugasundaram, Venugopal Gopikrishnan, and Ramasamy Balagurunathan. October 2016. Terpenoid bioactive compound from Streptomyces rochei (M32): Taxonomy, fermentation and biological activities. World J Microbiology and Biotechnology. 31; 161. [IF 4.2] 

176. Venugopal Gopikrishnan, Manikkam Radhakrishnan_, Raasaiyah Pazhanimurugan, Thangavel Shanmugasundaram, and Ramasamy Balagurunathan. April 2016. Quercetin from marine derived Streptomyces fradiae PE7: Taxonomy, fermentation, antifouling activity and characterization. J Environmental Science and Pollution Research [IF. 5.1].

177. Jerrine Joseph, T. Rajasekar and M. Radhakrishnan. March 2016. In vitro Cytotoxicity of methanol extracts of H.wightianum  and  H.hookerianum against 3T3L1  cell lines. Bangladesh J Pharmacology. 11(2); 328-329. [IF: 1.1]

178. Shekar, P., Sathishkumar, Gopikrishnan, V and Radhakrishnan, M. March 2016. HPTLC Fingerprint Profile of Antibacterial Compound Produced From Forest Soil Streptomyces SFA5. Bangladesh J Pharmacology. 11; 295-300. [IF: 1.1]

179. Gopikrishnan, V., M. Radhakrishnan, R. Pazhanimurugan, T. Shanmugasundaram and R. Balagurunathan. 2016. In vitro antimicrobial activity of actinobacteria isolated from South east coast of Tamil Nadu, India. Bangladesh J Pharmacology.  [IF: 1.1]

180. Radhakrishnan Manikkam, Sekar Ponnuswamy, Jerrine Joseph and Vanaja Kumar. July 2016. Antitubercular activity of pigment from forest soil Streptomyces sp SFA5. Bangladesh J Pharmacology. 11; 138-140. [IF: 1.1]

2015

181. Rajasekar, T,Anbarasu, S., Radhakrishnan, M., Jerrine, J* and Vanaja, K. Inhibitory activity of Euphorbia hirta (Tawa-tawa) extracts against Mycobacterium tuberculosis and other non-mycobacterial pathogens. Der Pharma Chemica.2015.7(8): 213-216.

182. Rajasekar, T., Priyadharshini, P., Deivasigamani, B*, Ilamathi, J., Kumaran, S., Edward, G.J.G. Enhancements of non-specific immune response in Mugilcephlus by seaweed extract against Vibrio alginolyticus (BRTR07). Journal of Coastal Life Medicine. 2015; 3(10): 776-786.

183. Sakthivel, M., Deivasigamani, B*., Rajasekar, T., Kumaran, S and Alagappen KM Immunostimulatory Effects of Polysaccharide Compound from Seaweed Kappaphycusalvarezii on Asian seabass (Latescalcarifer) and it’s Resistance against Vibrio parahaemolyticus. J Mar BiolOceanogr , 2015; 4:2.

184. Yeo ELL, Chua AJS, Parthasarathy K, Yeo HY, Ng ML, Kah JCY. 2015. Understanding aggregation-based assays: nature of protein corona and number of epitopes on antigen matters. RSC advances. [IF: 4.036]

185. Shekar Ponnuswamy, Sathishkumar Kannaiyan, Gopikrishnan Venugopal and Radhakrishnan Manikkam. August 2015. Antiproliferative activity of yellow pigment from forest soil Streptomyces sp SFA5 against breast cancer cell line MCF-7. Bangladesh J Pharmacology. 10; 714-715. [IF: 1.1]

186. Radhakrishnan, M., and R. Balagurunathan. 2015. Bioprospecting of actinomycetes from Indian rare ecosystems: an overview with experiences. Current perspectives in Microbiology. 4(1); 36-44.

187. Saravanan, D., and M. Radhakrishnan. August 2015. Isolation and optimization of agarase producing bacteria from marine sediments. International Journal of ChemTech Research. 8(4); 1701-1705.  

188. Gopikrishnan, V., M. Radhakrishnan, R. Pazhanimurugan, T. Shanmugasundaram and R. Balagurunathan. July 2015. Natural products: Potential and less explored source for antifouling compounds. Journal of Chemical and Pharmaceutical Research. 7(7); 1144-1153.

189. Sivaraj Anbarasu, Manikkam Radhakrishnan, Aumugam Suresh and Jerrine Joseph. March 2015. Phytochemical, Ethnomedicinal and pharmacological potentials of Seabuckthorn- A Mini-review. International Journal of Pharma and Biosciences. 

190. Saravanan, D., M. Radhakrishnan, and R. Balagurunathan. March 2015. Bioprospecting of bacteria from less explored ecosystem. Journal of Chemical and Pharmaceutical Research, 7(3); 852-857.

2014

191. Radhakrishnan_, M., V. Gopikrishnan_, S. Balaji_, R. Balagurunathan_, and Vanaja Kumar.^. November 2014. Bioprospecting of actinomycetes from certain less explored ecosystems active against Mycobacterium tuberculosis and other non-mycobacterial pathogens. International Scholarly Research Notices. Volume 2014, Article ID 812974, 9 pages (http://dx.doi.org/10.1155/2014/812974)

192. Radhakrishnan, M., R. Pazhanimurugan, V. Gopikrishnan, R. Balagurunathan and Vanajakumar. Feb 2014. Streptomyces sp D25 isolated from Thar Desert soil, Rajasthan producing pigmented antituberculosis compound only in solid culture. Journal of Pure and Applied Microbiology, 8(1); 333-337. 

193. Radhakrishnan, M., K.J. Samshath, and R. Balagurunathan. December 2014. Hydroxamate siderophore from Bacillus sp SD12 isolated from iron factory soil. Current World Environment. 9(3); 990-993.

194. Radhakrishnan, M., G. Vijayalashmi and R. Balagurunathan. December 2014. Optimization of Polyhydroxyalkanoates from marine Carnobacterium sp E3. Journal of Chemical and Pharmaceutical Research, 6(7); 45-480.

195. Radhakrishnan, M., V. Anuradha Raman,  S. Bharathi, R. Balagurunathan and Vanaja Kumar. December 2014. Anti MRSA and antitubercular activity of phenoxazinone containing molecule from Borra caves Streptomyces sp. BCA1. International Journal of Pharmaceutical Science and Research.5(12); 5342-5348.

196. Balaji, S., M. Radhakrishnan and R. Balagurunathan. July 2014. Intergenus protoplast fusion studies between marine Streptomyces sp. ANS4 and Escherichia coli. International Journal of Pharmacy and Pharmaceutical Sciences. 6(7); 466-469. 

197. Shekar, P., K. Sathish kumar, S. Anuradha Jabasingh, M. Radhakrishnan, and R. Balagurunathan. July 2014. Optimization of Medium Components for Antibacterial Metabolite production from marine Streptomyces sp. PUA2 using Response Surface Methodology. International Journal of Pharmacy and Pharmaceutical Sciences.6(7); 475-480. 

198. Mohana, S., and M. Radhakrishnan. Aug-Sep 2014. Streptomyces sp MA7 isolated from mangrove rhizosphere sediment effective against Gram negative bacterial pathogens.  International Journal of PharmTech Research, 6(4); 1259-1264. 

199. Vijitha Vijayan, M. Radhakrishnan and R. Balagurunathan. Aug-Sep 2014. Bioprospecting of endophytic actinomycetes for antiphytofungal activity. International Journal of ChemTech Research, 6(5); 2689-2694. 

200. Anbarasu. S., M. Radhakrishnan, A. Suresh, Jerrine Joseph, and Vanaja kumar. April 2014. Studies on antagonistic activity and probiotic properties of Enterococcus faecium and Lactococcus lactis. International J Pharma and Biosciences, 5(3): (B) 682 – 690. 

201. Saravanan, D., S. Bharathi, M. Radhakrishnan, and R. Balagurunathan. 2014. Production and optimization of L-glutaminase from Vibrio sp. M9 isolated from mahabalipuram marine sediments. World Journal of Pharmaceutical Research. 3(2):2117-2126. 

202. Rajasekar, T, Deivasigamani, B^*, Priyadharshini, P, Kumaran, S, Sakthivel, M., Balamurugan S., and Edward GnanaJothiG. Screening of marine seaweeds for bioactive compound against fish pathogenic bacteria and active fraction analyses by GCMS. Journal of Coastal Life Medicine, 2014; 2(5): 367-375.

2013

203. Radhakrishnan, M., R. Balagurunathan, M. Sakthivel_, R. Pazhanimurugan.  2013. Antibacterial substance from actinobacterial strain TA4 isolated from Western Ghats, India. Indian Journal of Applied Microbiology, 16(2); 9-16.

204. Bharathi, S., M. Nithya, D. Saravanan, M. Radhakrishnan and R. Balagurunathan. June 2013. Bioprospecting of coral reef-associated bacteria with special reference to anti-infective metabolites. Journal of Applied Pharmaceutical Science. 3(6); 164-167

205. Gopikrishnan, V., R. Pazhanimurugan, T. Shanmugasundaram, M. Radhakrishnan and R. Balagurunathan. 2013. Bioprospecting of actinobacteria from mangrove and estuarine sediments for antifouling compounds. International Journal of Innovation in Science, Engineering and Technology. 2(7); 2726-2735.

206. Pazhanimurugan, R., M. Radhakrishnan, V. Gopikrishnan, T. Shanmugasundaram, and M. Sanjivkumar and R. Balagurunathan. 2013. L-asparaginase and pectinase: Production and characterization of enzymes from extremophilic Streptomyces sp. M32. International Journal of Advances in Pharmaceutical Research (IF = 0.524)

207. Rajasekar, T, Deivasigamani, B, Priyadharshini, P, Kumaran, S, Sakthivel, M., Balamurugan S., and Edward GnanaJothi G. 2013. Antibacterial activity of marine seaweeds against clinical isolated pathogens and active compound identified by GCMS. Inventi Rapid: Pharm Biotech and Microbiology, 2014(1):1-9, 2013.

      

Book Chapters (2013-2025)

2025

1. Shreya R, Kishore Kumar A, Manigundan K, Thenmozhli GS, Ranjani S, Abirami B, Sakthi D., Karthik Prakash MP., Sai Mahesh Kumar S., Gopikrishnan V., Krupakar P & Radhakrishnan M.  (2025). Anti-infective Molecules (Antimicrobial Property) from Mangrove Microbiome. In: Muthusamy, S., Manikkam, R., Venugopal, G. (eds) Mangrove Microbiome. Springer, Singapore. https://doi.org/10.1007/978-981-96-2602-1_18

2. Ranjani S., and M. Radhakrishnan (2025). Determination of Anticancer Property of Mangrove Microbiome. In: Muthusamy, S., Manikkam, R., Venugopal, G. (eds) Mangrove Microbiome. Springer, Singapore. https://doi.org/10.1007/978-981-96-2602-1_20

3. Blessy Cleatus, Rajasekar Thirunavukkarasu, Subramanian Kumaran, James John. 2025. Oral microbiome and human health. In: Human and Animal Microbiome Engineering, Academic Press. 139-156.

2024

4. Shakila Harshavardhan, Vignesh Sounderrajan, Sam Ebenezer Rajadas, Krupakar Parthasarathy and Rohini Tamilanban. ‘Emerging Concepts in the Field of Vaccine Adjuvants’, in Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, ed. By Manickam Radhakrishnan and Krupakar Parthasarathy, August 2024 (Springer Publications), pp.1-7, (ISBN:978-981-97-1777-4). DOI:https://doi.org/10.1007/978-981-97-1777-4.

5. Balaji Subramanyam, Revathy Kalyanasundaram, Sam Ebenezer Rajadas & Vanaja Kumar. ‘Bacteriophages and Their Lysins as Potent Antibacterials’, in Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, ed. By Manickam Radhakrishnan and Krupakar Parthasarathy, August 2024  (Springer Publications), pp.251-262. (ISBN:978-981-97-1777-4). DOI:https://doi.org/10.1007/978-981-97-1777-4.

6. Vignesh Sounderrajan, Sam Ebenezer Rajadas, T. Thangam, Sudhanarayani S. Rao, Krupakar Parthasarathy, Rohini Tamilanban & Shakila Harshavardhan. ‘Host-Directed Immunotherapy for Tuberculosis’, in Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, ed. By Manickam Radhakrishnan and Krupakar Parthasarathy, August 2024 (Springer Publications), pp.323-335. (ISBN:978-981-97-1777-4). DOI:https://doi.org/10.1007/978-981-97-1777-4.

7. Sam Ebenezer Rajadas, Christy Rosaline, Keerthiga Krubanithy, Rohini Tamilanban & Anis Kumar Mani. ‘Biomaterials and Recent Advancements in Tailoring Approaches’, in Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, ed. By Manickam Radhakrishnan and Krupakar Parthasarathy, August 2024 (Springer Publications), pp.355-366.(ISBN:978-981-97-1777-4). DOI:https://doi.org/10.1007/978-981-97-1777-4.

8. Vignesh Sounderrajan, Sam Ebenezer Rajadas, T. Thangam, Sudhanarayani S. Rao, Sakthivel Jeyaraj, Krupakar Parthasarathy. 2024. Role of fat-soluble vitamins in combating Middle East Respiratory Syndrome (MERS).

9. Shakila Harshavardhan, Krupakar Parthasarathy. 2024. Emerging Concepts in the field of Vaccine Adjuvants Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, Springer Nature, Singapore Pte Ltd, [ISBN: 978-981-97-1776-7].            

10. Krupakar Parthasarathy. 2024. An Emerging Artificial Intelligence Tool for the Advancement of Modern Health Care in Tuberculosis. Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, Springer Nature, Singapore Pte Ltd. [ISBN: 978-981-97-1776-7]. 

11. V. Hari Balaji, Krupakar Parthasarathy. 2024. Role of Artificial Intelligence in the diagnosis and therapy of gynecological disorders: Opportunities and Challenges. Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, Springer Nature, Singapore Pte Ltd. [ISBN: 978-981-97-1776-7]. 

12. Supraja. K, Krupakar Parthasarathy. 2024. Translational research in COPD. Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, Springer Nature, Singapore Pte Ltd. [ISBN: 978-981-97-1776-7].

13. Sudhanarayani S Rao, Krupakar Parthasarathy. 2024. Opportunities, Challenges in Translation Vaccine research: Lesson learnt from Vaccine development during COVID-19 pandemic. Translational Research in Biomedical Sciences: Recent Progress and Future Prospects, Springer Nature, Singapore Pte Ltd. [ISBN: 978-981-97-1776-7].

14. Radhakrishnan M., GS. Thenmozhli, S. Ranjani, A. Kishore Kumar, S. Azhagesan, K. Manigundan, V.  Gopikrishnan, P. Krupakar, T. Shanmugasundaram, S Sasirekha & R Balagurunathan. 30 Aug 2024.Translational Research in Microbial Healthcare Products with Special Reference to Anticancer Drug Discovery from Actinobacteria. In: Translational Research in Biomedical Sciences: Recent Progress and Future Prospects. Springer. Pp. 145-165. DOI: https://doi.org/10.1007/978-981-97-1777-4_10 

15. Saravanan, TS, V. Gopikrishnan, M. Radhakrishnan, K. Manigundan, A. Kishorekumar., J Song and AJ Kasem Soytong. 30 Aug 2024. Translational Value of Natural Pigments with Reference to Healthcare and Cosmetic Applications. In: Translational Research in Biomedical Sciences: Recent Progress and Future Prospects. Springer. Pp. 235-250. DOI: https://doi.org/10.1007/978-981-97-1777-4_16 

2023

16. Sharon Beaula, Manigundan K., Ramesh Kumar, Kishore Kumar A., Radhakrishnan M., Gopikrishnan V., and Sakthivel K. 18^th Dec 2023. Extraction and Quantification of Saxitoxins from Aquatic Samples by LC-MS/MS. In: Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer

17. Manigundan K., Radhakrishnan M., Gopikrishnan V., and Sakthivel K. Jan 2023. Extraction and Quantification of Saxitoxins from Aquatic Samples by LC-MS/MS. In: Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer

18. Thenmozhli GS., Kishore Kumar A., Abirami B., Ranjani S., Radhakrishnan M., and Manigundan K. 18^th Dec 2023. Detection of Cyanotoxins using bacterial bioassays. In: Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. Springer

19. S. Bharathi, and M. Radhakrishnan*. Feb 2023. Biopreservation of food using bacteriocin. In: Postbiotics [Editor: Dhanasekaran. D]. Springer

20. Abirami B, Kishore Kumar A., Thenmozhli GS., Ranjani S., M. Radhakrishnan* and Gopikrishnan V. Feb 2023. Preparation of Postbiotics from Streptomyces sp. In: Postbiotics [Editor: Dhanasekaran. D]. Springer

21. Abirami B, Ranjani S, Kishore Kumar A, Thenmozhli GS., Gopikrishnan V., and M. Radhakrishnan*. Feb 2023.^. Analysis and spectral characterization of Exopolysaccharide Postbiotics by FT-IR and NMR. In: Postbiotics [Editor: Dhanasekaran. D]. Springer

22. Kishore Kumar A., Manigundan K., Abirami B., Ranjani S., Thenmozhli GS and M. Radhakrishnan*. Jan 2023. Analysis and identification of Biosurfactants Postbiotics. In: Postbiotics [Editor: Dhanasekaran. D]. Springer.

23. Thenmozhli GS., Ranjani S., Kishore Kumar A., Abirami B., M. Radhakrishnan*., and Gopikrishnan V. Jan 2023. Antibacterial activity of Postbiotics. In: Postbiotics [Editor: Dhanasekaran. D]. Springer.

24. Ranjani S., Thenmozhli GS., Abirami B., Kishore Kumar A., and M. Radhakrishnan*. Feb 2023. Antifungal activity of Postbiotics. In: Postbiotics [Editor: Dhanasekaran. D]. Springer.

25. Gopikrishnan, V., M. Radhakrishnan, K. Manigundan, S Usha Nandhini, S. Tamil Selvam, Bavanilatha M., J. Sheeba. Feb 2023. Isolation and identification of probiotics microorganisms. In: Postbiotics [Editor: Dhanasekaran. D]. Springer.

26. Bharathi, S., and M. Radhakrishnan. Jan 2023. Antioxidant activity of marine bacterial pigments. Marine Antioxidants Book. Ed. S Kim;  Elsevier.

27. Sudhanarayani S Rao, Vignesh Sounderrajan, Thangam T, Krupakar Parthasarathy*. 2023. Analysis and Identification of Postbiotic Enzymes. Postbiotics under Series Title Methods and Protocols in Food Science. Springer Nature, Humana, New York, NY, eBook ISBN 978-1-0716-3421-9. 

28. Vignesh Sounderrajan, Sudhanarayani S Rao, Thangam. T, Krupakar Parthasarathy*. 2023. Antiviral activity of Postbiotics. Postbiotics under Series Title Methods and Protocols in Food Science. Springer Nature, Humana, New York, NY, eBook ISBN 978-1-0716-3421-9. 

29. Jayanthi Palanivel, Thangam. T, Mohamed Jameer Basha Jahankir, Krupakar Parthasarathy*. 2023. Bacteriocin Postbiotics for tuberculosis drug development. Postbiotics under Series Title Methods and Protocols in Food Science. Springer Nature, Humana, New York, NY, eBook ISBN 978-1-0716-3421-9

30. Rajasekar Thirunavukkarasu *, P. Gayathri & V. Jeyanthi. 2023. Isolation of Toxin Producing Cyanobacteria from Aquatic Samples with Nostoc sp. In; Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin. 

31. V. Jeyanthi, Rajasekar Thirunavukkarasu & Kumaran Subramanian. 2023. Detection of Cyanotoxins Using Invertebrate Bioassays in Brine Shrimp. In: Protocols for Cyanobacteria Sampling and Detection of Cyanotoxin.

32. B. F. Paul Beulah & T. Rajasekar. 2023. Preparation of Postbiotics from Bacillus. In. Postbiotics (Springer)

33. K. Abirami Arasu & T. Rajasekar. 2023. Immunomodulatory Activity of Postbiotics from Lactobacillus. In: Post biotics. (Springer)

34. M. Arputha Bibiana, L. Karthik, K. Gunasekaran, T. Rajasekar. 2023. In Vivo Immunomodulatory Study of Postbiotics in Mice. In: Postbiotics (Springer)

35. P. Sujith, T. Rajasekar. 2023. Postbiotic Food Packaging Using Bacteriocin. In: Postbiotics. (springer)

2022

36. Bharathi, S., and M. Radhakrishnan. 17^th Nov 2022. Citric Acid Production. Industrial Microbiology based entrepreneurship. Amaresan, Dhanasekar and Cundell (Ed). 67-78. Springer

37. Abirami, B., M. Radhakrishnan*, and PV. Bhaskar. October 2022. Microbial symbionts of polar animals. In. Microbial Symbionts: Functions and Molecular Interactions on Host; Elsevier Editor. D. Dhanasekar. Pp. 573-583.

38. Bharathi, S., and M. Radhakrishnan. October 2022. Symbiotic Microbes from Corals. In. Microbial Symbionts: Functions and Molecular Interactions on Host; Elsevier Editor. D. Dhanasekar. Pp. 441-450. 

39. Gopikrishnan V., M. Radhakrishnan, P Krupakar, K Manigundan, B Abirami and S Reshma. October 2022. Endosymbiotic interactions of actinobacteria with the insects. In. Microbial Symbionts: Functions and Molecular Interactions on Host; Elsevier Editor. D. Dhanasekar. Pp. 645-658.

40. Manigundan.K, B. Abirami, V. Gopikrishnan, M. Radhakrishnan and P.V. Bhaskar. Jan 2022. Isolation of psychrophilic and psychrotolerant actinobacteria. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 141-144.

41. B. Abirami, M. Radhakrishnan, K. Manigundan, V. Gopikrishnan, S.T. Somasundaram, and P.V. Bhaskar. Jan 2022. In vitro evaluation of actinobacterial extracts for immunomodulatory properties. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. Pp 471-474.

42. B. Abirami, M. Radhakrishnan, K. Manigundan, V. Gopikrishnan, S.T. Somasundaram, and P.V. Bhaskar. Jan 2022. Screening and production of antifreeze proteins from actinobacteria In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. Pp 467-470.

43. B. Abirami, M. Radhakrishnan, K. Manigundan, Jerrine Joseph, V. Gopikrishnan and R. Balagurunathan. Jan 2022. Miniaturized production of bioactive extracts from actinobacteria. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. Pp 367-370.

44. K. Manigundan, B. Abirami, V. Gopikrishnan and M. Radhakrishnan. Jan 2022. Screening of actinobacteria for microbial induced calcium precipitation (MICP). In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 487-489.

45. B. Abirami, K. Manigundan, , Jerrine Joseph, S. Shanmugasundaram and M. Radhakrishnan. Jan 2022. In vitro evaluation of actinobacterial extracts for anti inflammatory properties. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 463-466.

46. K. Manigundan, B. Abirami, V. Gopikrishnan, Jerrine Joseph and M. Radhakrishnan. Jan 2022. PCR based determination of secondary metabolite genes in actinobacterial cultures. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 263-266.

47. Gopikrishnan, V., K. Manigundan, PR. Meganathan, M. Radhakrishnan. Jan 2022. Bioleaching of heavy metals from e-waste using actinobacteria. In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 705-708.

48. Gopikrishnan, V.,K. Manigundan, B. Abirami, and M. Radhakrishnan. Jan 2022. Immobilization of actinobacterial cells – Sodium alginate and Calcium chloride method In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 491-494.

49. Gopikrishnan, V., M. Radhakrishnan, K. Manigundan T. Shanmugasundaram, Jerrine Joseph. Jan 2022. In vitro evaluation of antimitotic properties of actinobacterial extracts using onion root tip assay In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. Pp 449-451.

50. Jerrine Joseph.,M. Radhakrishnan, K. Manigundan,V. Gopikrishnan, Mary Shamyaand Wilson Aruni. Jan 2022. Methods of identification and validation of drug target In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 335-338.

51. Manigundan, K., Jerrine Joseph, M. Radhakrishnan, Mary Shamya and Wilson Aruni. Jan 2022. Application of bioinformatic tools for phylogenetic analysis In: Methods in Actinobacteriology Book. Ed. D. Dhanasekaran. Springer. ISBN: 978-1-0716-1728-1. pp 187-191.

2021

52. Abirami B, K. Manigundan, M. Radhakrishnan*, V. Gopikrishnan, PV. Bhaskar, T. Shanmugasundaram and Syed G Dastager. April 2021. Diversity and bioprospecting potentials of Antarctic (polar) Microbes. (Book chapter In: Host Microbe Interactions – Eds Dhansekar et al., CRC Press). Pp. 349-365.  ISBN: 978-0-367-47990-9 (hbk)

2020

53. Jerrine Joseph, Bhaskaran Abirami, Kaari Manigundan, Venugupal Gopikrishnan and Manikkam Radhakrishnan*. March 2020. Antimicrobial peptides from actinobacteria - current status and future prospects. Microbial macromolecules (Elsevier).

54. Manikkam Radhakrishnan*, Kaari Manigundan, Venugopal Gopikrishnan, and Ramasamy Balagurunathan. August 2020. Screening methods for the detection of antagonistic actinobacteria: facts and problems. In: Recent Advances in Microbiology and Biotechnology. BookPI Publisher, Wesbengal, India. Book PI Publisher 

55. Bharathi, S., and M. Radhakrishnan. August 2020. Nanoparticles in Environmental Cleanup. In Recent Advances in Microbiology and Biotechnology. BookPI Publisher, Wesbengal, India. Book PI Publisher

56. Venugopal Gopikrishnan*, Angamuthu Vignesh, Kaari Manigundan, Manikkam Radhakrishnan and Jerrine Joseph. April 2020. Actinobacteria in earthworm cast and gut : Distribution and bioactivities. Recent Advances in Biology. Book PI. 

57. Jerrine Joseph., Manikkam Radhakrishnan, A.Mary Shamya and Wilson Aruni. July 2020.  Bar Coding Significance in Establishing Evolutionary Link in Plants. In: Cucurbita: Biology, Distribution and Habitat. Nova scientific publishers (USA). ISBN: 978-1-53617-924-8

2019

58. Gopikrishnan, V., A. Vignesh, M. Radhakrishnan, Jerrine Joseph, T. Shanmugasundaram, Mukesh Doble and R. Balagurunathan. October 2019. Microbial leaching of heavy metals from E-waste: Opportunities and challenges. In: Biovalorization of wastes to renewable chemicals and biofuels. Elsevier. 189-221.

59. Radhakrishnan Manikkam, Premalata Pati, Shanmugasundaram Thangavel, Gopikrishnan Venugopal, Jerrine Joseph, Balagurunathan Ramasamy and Syed G Dastager.^. June 2019. Distribution and bio-prospecting potential of actinobacteria from Indian Mangrove Ecosystems. In: Microbial Diversity: Ecosystem Sustainability and Biotechnological Applications (Springer) 

2018

60. Vaishnavi Chandramouli, Anusha Ramasamy, Jerrine Joseph and Radhakrishnan Manikkam*. July 2018. Pharamacological Significance of Cassia auriculata. In: “Recent Trends in Phytochemistry, Pharmacognosy and Pharmacobiotechnology of medicinal Plants”.

2017

61. Radhakrishnan Manikkam, Jerrine Joseph, Anbarasu Sivaraj, Suresh Arumugam, and Balagurunathan Ramasamy. July 2017. Actinobacteria from less explored ecosystems: A promising source for anti TB metabolites. (Book Chapter). In: Current Research in Microbiology (Online), USA. 1-29. (ISBN : 978-93-87500-01-3)

2014

62. Balagurunathan, R., M. Radhakrishnan and S. Ramya. November 2014. Extremophilic and extremotolerant Actinomycetes: Distribution and Importance. In: Recent Trends in Microbial Diversity and Bioprospecting. Westville Publishing House, New Delhi (ISBN: 978-93-83491-14-8); pp. 114-128.

     

Books (2013-2025)

1. Sanjivkumar M, M. Radhakrishnan and V. Gopikrishnan. 12^th March 2025. Mangrove microbiome: Diversity and Bioprospecting.  Springer.  Pp. 1-510. [e-ISBN: 978-981-96-2602-1]. DOI: https://doi.org/10.1007/978-981-96-2602-1

2. Krupakar Parthasarathy and Radhakrishnan Manikkam. 30^th Aug 2024. Translational Research in Biomedical Sciences: Recent Progress and Future Prospects. Springer. Pp: 1 - 390. [ISBN: 978-981-97-1777-4] [DOI: https://doi.org/10.1007/978-981-97-1777-4]

3. R. Balagurunathan, Radhakrishnan, M., T. Shanmugasundram., V. Gopikrishnan, and Jerrine Joseph. 12^th July 2020. Protocols in Actinobacterial Research. In. Springer Protocols Handbook Series. (Springer New York, NY). pP. 245. 2020 ISBN 978-1-0716-0728-2

4. Annadurai A., M. Radhakrishnan and V. Gopikrishnan. June 2020. Plant extracts acting as corrosion inhibitors fo steel reinforcement. LAP Lambert Academic Publishing. PP. 1-53 (ISBN: 978-620-2-67049-4)

5. Vaishnavi Chandramouli, Anusha Ramasamy, Radhakrishnan Manikkam and Jerrine Joseph. July 2018. Taxonomy, Distribution, Phytochemistry and Biomedical activities of selected Indian medicinal plants. Lambert Academic Publishing (Germany). Pp – 1-53.[ISBN: 978-613-9-87791-1] 

6. Radhakrishnan, M., R. Balagurunathan, V. Gopikrishnan, T. Shanmugasundram., Premalata Pati and Jerrine Joseph. August 2018. Fermentation Technology. – Laboratory Manual. Lambert Publishing (ISBN: 978-3-659-67878-3). Pp . 1-53. 2018

7. Suresh, A., M. Radhakrishnan, Jerrine Joseph et al., 2016. A portrait of the Mycobacterium tuberculosis cell wall targets. LAMBERT Academic Publishing, (Germany). Pp -1-73.

    

Conference Publications (2013-2025)

1. Muthuraman Muthuchamy, Manikannan Mathaiyan, Krupakar Parthasarathy, Lavanya Babu, Luke Elizabeth Hanna. 2020. Effects of marine extracts on augmenting cytokine production and its anti-tumor activity. International Science Symposium on HIV and Infectious Diseases (ISSHID 2019): Infectious diseases. Springer Nature. BMC Proceedings. [ISSN: 1753-6561]

2. Manikannan Mathaiyan, Lavanya Babu, Krupakar Parthasarathy. 2020. Marine brown algal compounds inhibits HSV-2, an in vitro analysis. International Science Symposium on HIV and Infectious Diseases (ISSHID 2019): Infectious diseases. Springer Nature. BMC Proceedings. [ISSN: 1753-6561]

3. Krupakar Parthasarathy. Current Scenario of Dengue infections and Therapeutics in India. 2017. Asia Pacific Conference of Emerging Viral Infections organized by Centre for Dengue Research, University of Sri Jayewardenepura, Sri Lanka. International Conference proceedings.

4. Krupakar Parthasarathy. Dengue current Therapeutics and challenges. 2017. International symposium on Major Southeast Asia infectious diseases & Taiwan-Japan joint symposium on cell signaling and gene regulation, conducted by Center of Infectious Disease and Signaling Research (CIDSR), NCKU, Taiwan. International Conference proceedings.

List of MoUs 

Industry collaboration

Clinical partners

List of Patents

Research Team

Research Team

Dr. Radhakrishnan Manikkam, working as Professor (Research) & in-charge, at the Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai. He completed his Ph.D in Microbiology at National Institute for Research in Tuberculosis (ICMR), Chennai. He has 16 years of research experience and 4 years of teaching experience. He is pursuing his research on “Ecology, diversity, taxonomy and bioprospecting potentials of Actinobacteria from rare ecosystems. He has received 10 research projects (5 as PI and 5 as Co-PI) from different funding agencies in India for pursuing research on Actinobacteria. Since 2019, he is started working on investigating microbial resources from Cryosphere regions such as Antarctic Ocean, Arctic and the Indian Himalayan Region. He has participated in the 11^th Indian Scientific Expedition to Antarctic Ocean during 2020 and 1^st Ever Arctic Winter Expedition during 2024 to explore Actinobacteria. He has published 159 journal articles, 45 book chapters and edited 7 books. He is guiding 8 students for Ph.D. At the bioprospecting division, his team maintaining 1200 bacterial cultures including 400 actinobacteria isolated from different parts of India and also from polar regions for exploring their bioprospecting potential.

Dr. Krupakar Parthasarathy is a Professor (Research) at the Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai. He holds a Ph.D. from Nanyang Technological University, Singapore, with expertise in molecular biology, biophysics, chemical biology, and structural biology. His research focuses on virology, drug discovery, and computational biology. He has received multiple awards, including the NTU Alumni Service Award and the Young Scientist Award from DST-SERB, and has contributed significantly to high-impact scientific publications, patents, and ongoing research projects. His work spans areas such as SARS-CoV-2 structural analysis, AI-driven diagnostics, and infectious disease therapeutics. He is in charge of the biosafety 2-plus laboratory facility for Virology and Mycobacteriology, Genomics and proteomics lab and Translational Immunology, FACS Multi-omics Core Facility and Vaccine Research Lab.

Dr. Gopikrishnan Venugopal is working as an Assistant Professor (Research), Bioprospecting division, Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai. He is working in the field of actinobacterial research for the past 14 years. He obtained his doctoral degree at Actinobacterial Research Lab, Department of Microbiology, Periyar University, Tamil Nadu. Currently he is working on research areas like associated actinobacteria mainly fish gut, earthworm cast and gut, insect nest, marine biofouling, antibiofouling com-pounds, natural pigments, enzymes, and bioactive com-pounds. As Principal Investigator, he has completed one DST SERB project as PI and executing one MOES funded project on fish gut associated bacteria. He has published 62 research articles both national and international journals, 3 manuals, and 11 book chapters on actinobacteria.

Dr. T. Rajasekar is currently serving as an Assistant Professor (Research) in the Centre for Drug Discovery and Development at Sathyabama Institute of Science & Technology, India. His research focuses on Molecular Immunology and the exploration of Immunostimulants derived from seaweeds and plants to combat human pathogens. Dr. Rajasekar has a strong interest in bioprospecting seaweeds for applications in drug-resistant pathogens, antibiofilm agents, and anticancer compounds. His work also extends to sustainable biomaterials, nanocomposite-based sensors for healthcare, and immunotechnology, aiming to develop innovative solutions that address pressing global health challenges. Dr. Rajasekar actively contributes to the scientific community as an editorial board member and peer reviewer for several esteemed international journals. He is also affiliated with numerous international organizations, further strengthening his contributions to the field. In addition to his research endeavours, he has successfully fulfilled various administrative responsibilities. His scholarly work includes the authorship of multiple research articles and books related to Molecular Immunology and Immunostimulants from seaweeds and plants, which have significantly enriched scientific knowledge in these areas.

Dr. R. Sam Ebenezer is a microbiologist specializing in tuberculosis immunology, with over 9 years of research experience in Immunology, microbiology, molecular techniques, and animal studies. He holds a Ph.D. in Biotechnology from Madurai Kamaraj University, where he explored the immunomodulatory effects of immune complexes in TB. He began his research career at TANUVAS, working on swine fever virus vaccine development. He later contributed to TB diagnostics and training programs at ICMR-NIRT, including validation of the TruNAAT kit and the ECHO model for drug-resistant TB education. A recipient of the prestigious ICMR Post-Doctoral Fellowship (2019), he conducted strain-specific TB immunology research at ICMR-NIRT, Chennai. He has published 20 peer-reviewed articles in leading journals such as Scientific Reports, PlosOne, IJMR, and Frontiers in Microbiology. He is TN-SET-qualified and currently serves as an Assistant Professor (Research) in the Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology. He is trained to work in BSL-3 containment facilities and is skilled in mycobacterial culture and diagnostics assay development. Currently, his research focus is on the development of novel efflux inhibitors associated with TB drug resistance and tailor-made vaccine constructs for TB.

Research Labs and Facilities at CDDD – Sathyabama

FACS Multi-Omics Core Facility (FMCF)

Instagram: https://www.instagram.com/fmcf_sist?igsh=NmxpNG4xaXJoMzkz

LinkedIn: https://www.linkedin.com/in/fmcf-cddd-sist-963952361/

The FACS Multi-Omics Core Facility (FMCF) at the Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology, Chennai, is a state-of-the-art research infrastructure designed to advance high-resolution cellular and molecular investigations. The facility integrates flow cytometry, single-cell transcriptomics, and multi-omics platforms to drive innovation across biomedical, translational, and environmental research.

Cutting-Edge Instrumentation

The FMCF houses advanced analytical systems including:

• BD FACSAria™ Fusion (Analyser & Sorter): Enables precise cell sorting and high-throughput flow cytometry.

• BD FACSLyric™ (Analyser): Delivers flexible multiparameter immunophenotyping and detailed cellular analysis.

• BD Rhapsody™ HT Xpress Single-Cell Analysis System: Provides powerful single-cell transcriptome profiling with integrated analysis capabilities.

These technologies create a comprehensive platform for cell sorting, transcriptome analysis, and multi-omics data integration.

Salient Features

• Accelerates Multidisciplinary Research: Supports diverse areas including drug discovery, regenerative medicine, and molecular biology.

• Integrated Platform: Enables seamless analysis, sorting, and single-cell transcriptomic profiling.

• Facilitates Translational Innovation: Bridges academic research with industrial and clinical applications.

• Supports Bioactive Molecule Discovery: Enhances efforts to identify novel therapeutic targets and compounds.

• Empowers Genome Engineering: Facilitates CRISPR-based gene editing and functional genomics studies.

Core Areas of Research

• Drug Discovery & Vaccine Development: Small molecule mechanisms, TCR/BCR repertoire, sample multiplexing.

• Stem Cell & Regenerative Biology: Organoid and culture system analysis.

• Targeted RNA Sequencing & Whole Transcriptomics

• Cancer Biology: Diagnostic and histopathological evaluation.

• Virus Characterization: Analysis of virus-like particles and bacteriophages.

• Infectious Diseases: Mechanistic studies and granuloma modeling.

• Protein Expression & CRISPR Screening

• Developmental Biology: Study of developmental stages and cellular mechanisms.

• Environmental Biotechnology: Detection of marine picoplankton and biofilm formation.

The FMCF provides a powerful platform for unlocking complex biological systems, advancing translational research, and driving discoveries that impact medicine, industry, and the environment.

For Consultancy and Collaboration:

Contact: Dr. Krupakar Parthasarathy

Mobile: +91 9176163111

Semi-Prep-LC MSD 

Semi-preparative HPLC coupled with mass spectrometry (HPLC–MS) at our centre serves as a powerful, central analytical platform with wide-ranging applications across sectors such as environmental science, health and biomedical research, forensics, food and beverage testing, industry, agriculture, and biopharmaceutics. In environmental monitoring, it enables precise detection of xenobiotics and pollutants in water and soil. In the biomedical field, it aids in purifying and identifying biomolecules like amino acids, peptides, and nucleotides. Forensic applications benefit from its sensitivity in analysing psychoactive substances and biological fluids. The food industry uses it to detect additives, sweeteners, and pesticide residues, while industrial sectors utilize it for effluent testing. In agriculture, it helps identify and characterize pesticides and herbicides, and in biopharmaceutics, it supports antibody testing, chiral drug analysis, and peptide fingerprinting. This system’s ability to purify and characterize compounds simultaneously makes it indispensable for both research and applied sciences.

Flash Chromatography for natural product separation

Flash chromatography is a versatile technique primarily used for the rapid purification of organic compounds, making it an essential tool in natural product research, medicinal chemistry, and synthetic organic chemistry. It is commonly applied to separate complex mixtures such as plant extracts, reaction intermediates, and bioactive fractions based on polarity or molecular interactions. In pharmaceutical development, flash chromatography aids in isolating lead compounds and purifying synthetic drug candidates. Its scalability and speed also make it valuable in food science for separating additives and contaminants, and in academic or industrial labs for routine purification tasks. The technique supports both analytical and preparative workflows, serving as a cost-effective alternative to more sophisticated chromatographic methods for initial compound enrichment.

Contact: Dr. M. Radhakrishnan, Professor (Research)

Mobile: 9361761697

Early stage drug discovery platform @ CDDD – Sathyabama

Events at CDDD – Sathyabama (2013-2025)